Clinical trial · Interventional
Tai Chi for Reducing Aromatase Inhibitor-Induced Arthralgia
Evaluating Tai Chi for Reducing Aromatase Inhibitor-Induced Arthralgia in Breast Cancer Survivors
NCT07737951CI-TRIAL-00122063recruitingN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The objective of the pilot RCT is to evaluate the feasibility and acceptability of a Tai Chi intervention "TaiChi4Joint" vs. an HE AC group for relieving AIIA in women with hormone receptor positive stage I-III BCa. The investigators will pilot test our data collection for mechanism measures via three innovatively integrated biobehavioral pathways.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Breast Cancer | Malignant Breast Neoplasm | CURATED_EXACT | 0.92 |
| Hormone Receptor Positive Breast Carcinoma | Hormone Receptor-Positive Breast Carcinoma | ONTOLOGY_EXACT | 0.98 |
| Postmenopausal | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Health Education | Behavioral | — | UNRESOLVED |
| Tai Chi | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- TaiChi4Joint
- description
- Participants randomized to the TaiChi4Joint group will attend virtual Tai Chi classes via Zoom (1 hour, twice weekly for 12 weeks). At the first class, participants will review a Tai Chi safety and modifications handout. Using a manualized approach, each session includes structured objectives and activities to progressively learn simplified Tai Chi forms, with weekly verification of skill attainment. Six core elements are emphasized: (1) mindfulness (present-focused attention); (2) postural alignment (efficient, upright movement); (3) natural breathing (integrated with movement); (4) active relaxation (remaining relaxed while moving); (5) slow movement (building strength and endurance); and (6) integrated movement (coordinating functional movements).
- interventionNames
- Behavioral: Tai Chi
- type
- ACTIVE_COMPARATOR
- label
- Health Education Attention Control
- description
- To control for the attention that the TaiChi4Joint group receives, women randomized to the AC group will participate Routine virtual AC group classes via Zoom or via video link for 1 hour, twice a week, for 12 weeks, including survivorship content or healthy eating. The AC group is designed to control for attention and for expectations about getting some benefits from the treatment. The AC group is controlled for time and will also be 1 hour each time, twice a week, matching the frequencies and intensity of the intervention group.
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: -Individuals must meet all the following inclusion criteria in order to be eligible to participate in the study: * Age ≥18 years * Diagnosis of stage I-III hormone receptor-positive breast cancer * Postmenopausal * Currently receiving an aromatase inhibitor (anastrozole, letrozole, or exemestane) or within 5 years of initiation * Report joint pain that started or worsened after initiation of AI therapy * Report worst pain in the past week ≥3 on the BPI (0-10 scale) * Able to complete study procedures in English * Willing to be randomized to an intervention or attention control group and adhere to study procedures Exclusion Criteria: -An individual who meets any of the following criteria will be excluded from participation in this study: * Undergoing active cancer treatment (excluding endocrine therapy) * Uncontrolled cardiac or pulmonary disease that would limit safe participation * Currently engaged in regular structured moderate- or vigorous-intensity exercise (e.g., brisk walking, jogging/running, cycling, swimming, aerobic classes, or resistance training) totaling ≥150 minutes per week over the past 3 months * Currently participating in Tai Chi, yoga, Pilates, or other structured mind-body practice ≥2 times per week over the past 3 months * Joint pain due to inflammatory arthritic conditions * Recent surgery or joint injection within the past 4-6 weeks * Initiation or dose change of corticosteroids or opioids within the past 4 weeks * Planned discontinuation of AI therapy within the next 6 months * This study is limited to women with breast cancer, as \<1% of cases occur in men and data on AIIA in male patients are limited
References
Publications (0)
Data not yet available
No reference posted for this study.