Clinical trial · Observational
Analysis of Breath Volatile Organic Compounds Using Mass Spectrometry
Breath Volatile Organic Compounds (VOC) Analysis Using Proton Transfer Reaction Mass Spectrometry (PTR-MS)
NCT07732686CI-TRIAL-00119721not yet recruitingClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this clinical trial is to evaluate whether volatile organic compound (VOC) signatures detected in the breath of patients with cancer can serve as a potential screening tool for the early detection of cancer.
Conditions
Conditions (9)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Bladder Cancer | Malignant Bladder Neoplasm | CURATED_EXACT | 0.92 |
| Breast Cancer | Malignant Breast Neoplasm | CURATED_EXACT | 0.92 |
| Colon Cancer | Malignant Colon Neoplasm | CURATED_EXACT | 0.92 |
| Head and Neck Cancer | Malignant Head and Neck Neoplasm | ALIAS | 0.90 |
| Hepatocellular Carcinoma | Hepatocellular Carcinoma | ONTOLOGY_EXACT | 0.98 |
| Lung Cancer | Malignant Lung Neoplasm | CURATED_EXACT | 0.92 |
| Other Cancer | — | UNRESOLVED | — |
| Ovarian Cancer | Malignant Ovarian Neoplasm | CURATED_EXACT | 0.92 |
| Pancreas Cancer | Pancreatic Carcinoma | ALIAS | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Proton Transfer Reaction Mass Spectrometry Analysis | Device | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- Diagnosed Malignancies
- description
- Participants in this group either have a newly diagnosed, untreated cancer or a pre-existing cancer diagnosis but are not currently receiving anticancer therapy. Participants with a pre-existing diagnosis must not have received any anticancer treatment within the previous month.
- interventionNames
- Device: Proton Transfer Reaction Mass Spectrometry Analysis
- label
- Healthy Control Group
- description
- Participants in this control group have no current or prior diagnosis of a malignancy.
- interventionNames
- Device: Proton Transfer Reaction Mass Spectrometry Analysis
Primary outcomes (2)
- measure
- VOC Signature Collection.
- timeFrame
- 2 Years
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Age ≥ 18 at the time of consent. Male and female patients to be tested. * Capable of understanding written and/or spoken English language. * Able to provide informed consent. * Cancer of any type. * Newly diagnosed cancer and untreated or established diagnosis of cancer. For established cancer patients, no active anti-cancer treatment for more than one month (reasons for no treatment are such as relapse, progression of cancer, refractory, or intolerance to treatment etc.) Exclusion Criteria: * Under the age of 18. * Anticipated inability to complete breath sampling procedure. * Unable to provide informed consent. * Pregnant women * Active respiratory infection symptoms * Recent use of antibiotics * Difficulty in performing coached exhalation * Individuals who are unable to follow the instructions * Cancer patients who are on active treatment for cancer or have received cancer treatment within one month
References
Publications (0)
Data not yet available
No reference posted for this study.