Clinical trial · Interventional
Early Cognitive Interventions in Digital Format for Cancer Survivors
Early Cognitive Interventions in Digital Format for Cancer Survivors - INCOTEM
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The aim of this study is to evaluate the usability and effectiveness of two professionally supervised home-based cognitive training interventions as part of an early rehabilitation protocol for cancer-related cognitive impairment. Participants will be randomized to one of the two intervention arms (computerized cognitive intervention or virtual reality cognitive intervention) or to the control group. Participants of the intervention groups will be assessed before and after the 10 weeks intervention or at equivalent time points for the control group. Comparisons between experimental and control participants, and between the participants in the two intervention arms, will be carried out to see which intervention is most effective and accepted.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer | Malignant Neoplasm | ALIAS | 0.90 |
| Cognitive Change | — | UNRESOLVED | — |
| Cognitive Impairment | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Computerized cognitive treatment | Behavioral | — | UNRESOLVED |
| Virtual reality cognitive training | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- type
- EXPERIMENTAL
- label
- Computerized cognitive training - BrainHQ
- description
- The arm will follow the cognitive training program BrainHQ.
- interventionNames
- Behavioral: Computerized cognitive treatment
- type
- EXPERIMENTAL
- label
- Virtual Reality cognitive training - Enhance VR
- description
- The arm will follow the cognitive training program Enhance VR.
- interventionNames
- Behavioral: Virtual reality cognitive training
- type
- NO_INTERVENTION
- label
- Control Group
- description
- The arm will receive usual care with no cognitive intervention
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Patients over 18 years of age diagnosed with cancer (stage I-III) * Subjective complaints of cognitive functioning related to the diagnosis of cancer and/or cancer treatments * Between 1-6 months after completion of chemotherapy treatment * To have Wi-Fi and a computer/tablet * To sign the informed consent form Exclusion Criteria: * Previous history of cancer diagnosis * Anticipated change in cancer treatment/general medical treatment during the intervention period * Previous diagnosis of cognitive impairment * Diagnosis of other neurological or psychiatric diseases * Diagnosis of severe untreated depression * History of episodes of vertigo, epilepsy or seizures * Currently undergoing or having undergone any other type of intervention aimed at improving cognitive functioning (e.g., CRCI workshops) * Severe visual or hearing difficulties that may affect the performance of the intervention exercises * Inability to speak, understand, read, and write Spanish correctly * Failure to sign the informed consent form
References
Publications (16)
- BACKGROUNDZeng Y, Guan Q, Su Y, Huang Q, Zhao J, Wu M, Guo Q, Lyu Q, Zhuang Y, Cheng AS. A self-administered immersive virtual reality tool for assessing cognitive impairment in patients with cancer. Asia Pac J Oncol Nurs. 2023 Feb 28;10(3):100205. doi: 10.1016/j.apjon.2023.100205. eCollection 2023 Mar. PMID 37012969
- BACKGROUNDWu LM, Amidi A, Tanenbaum ML, Winkel G, Gordon WA, Hall SJ, Bovbjerg K, Diefenbach MA. Computerized cognitive training in prostate cancer patients on androgen deprivation therapy: a pilot study. Support Care Cancer. 2018 Jun;26(6):1917-1926. doi: 10.1007/s00520-017-4026-8. Epub 2017 Dec 27. PMID 29282534
- BACKGROUNDVon Ah D, Crouch A, Storey S. Acceptability of computerized cognitive training and global cognitive stimulating-based games delivered remotely: Results from a randomized controlled trial to address cancer and cancer-related cognitive impairment in breast cancer survivors. Cancer Med. 2023 Jun;12(11):12717-12727. doi: 10.1002/cam4.5904. Epub 2023 Apr 11. PMID 37039279
- BACKGROUNDVon Ah D, McDonald BC, Crouch AD, Ofner S, Perkins S, Storey S, Considine R, Unverzagt F. Randomized double-masked controlled trial of cognitive training in breast cancer survivors: a preliminary study. Support Care Cancer. 2022 Sep;30(9):7457-7467. doi: 10.1007/s00520-022-07182-4. Epub 2022 Jun 1. PMID 35648204
- BACKGROUNDSerweta-Pawlik A, Lachowicz M, Zurek A, Rosen B, Zurek G. Evaluating the Effectiveness of Visuospatial Memory Stimulation Using Virtual Reality in Head and Neck Cancer Patients-Pilot Study. Cancers (Basel). 2023 Mar 7;15(6):1639. doi: 10.3390/cancers15061639. PMID 36980525
- BACKGROUNDRunowicz CD, Leach CR, Henry NL, Henry KS, Mackey HT, Cowens-Alvarado RL, Cannady RS, Pratt-Chapman ML, Edge SB, Jacobs LA, Hurria A, Marks LB, LaMonte SJ, Warner E, Lyman GH, Ganz PA. American Cancer Society/American Society of Clinical Oncology Breast Cancer Survivorship Care Guideline. J Clin Oncol. 2016 Feb 20;34(6):611-35. doi: 10.1200/JCO.2015.64.3809. Epub 2015 Dec 7.