Precision Integrated Strategies and Efficacy Evaluation for Biliary Tract Cancers: An Umbrella Platform Study

Inclusion Criteria:

* The patient voluntarily joins this study and signs the informed consent form.
* Age: ≥18 years, male or female.
* Histologically or cytologically confirmed advanced biliary tract malignancies, including intrahepatic cholangiocarcinoma, extrahepatic cholangiocarcinoma, and gallbladder cancer.
* No prior systemic therapy for advanced BTC (biliary tract cancer).
* At least one measurable lesion as per RECIST v1.1 (spiral CT scan long diameter ≥10 mm or short diameter of enlarged lymph node ≥15 mm; lesions previously treated with local therapy may be considered target lesions only after documented progression according to RECIST v1.1).
* ECOG performance status: 0-1.
* Expected survival ≥12 weeks.
* Adequate major organ function.
* Female subjects of childbearing potential must have a negative pregnancy test (serum or urine) within 7 days before the first dose, must not be breastfeeding, and must voluntarily agree to use effective contraceptive measures during the study period and for 6 months after the last dose of chemotherapy. For male subjects with a female partner of childbearing potential, they must be surgically sterile or agree to use effective contraceptive measures during the study period and for 3 months after the last dose of chemotherapy; sperm donation is not allowed during the study.
* Subjects are expected to have good compliance and be able to follow the protocol requirements for efficacy and adverse event follow-up.

Exclusion Criteria:

* Has another active malignancy other than BTC within 5 years or concurrently.
* Has poorly controlled cardiac clinical symptoms or diseases.
* Has hypertension that cannot be reduced to normal range with antihypertensive medication; has a history of hypertensive crisis or hypertensive encephalopathy.
* Any clinically significant gastrointestinal disorders, including bleeding, inflammation, obstruction, or diarrhea \> grade 2.
* Has experienced thrombotic or embolic events within 6 months before the start of study treatment.
* Use of strong CYP3A4/CYP2C19 inducers (including rifampin and its analogues, and St. John's Wort) or strong CYP3A4/CYP2C19 inhibitors and/or strong UGT1A inhibitors within 14 days prior to signing the informed consent form.
* Has uncontrolled infection at screening.
* Patients with congenital or acquired immunodeficiency.
* Has a history of brain metastases or has brain metastases.
* Women who are pregnant or plan to become pregnant during the study treatment period.
* Other patients deemed unsuitable for inclusion by the treating physician.