Clinical trial · Observational
Radiation Therapy and Thymus Function in Young Women With Breast Cancer
Off-Target Effects of Breast Cancer Adjuvant Radiation Therapy on Thymus Function in Young Women
NCT07725172CI-TRIAL-00124620recruitingClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 30, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260930-000001
Summary
Brief summary (as posted)
Breast cancer treatment sometimes includes radiation to the breast or chest wall. There is a small gland, called the thymus, located in the upper chest that may receive a small amount of the radiation aimed at the breast. The goal of this study is to collect blood samples from young women with breast cancer to study the effect of radiation therapy on the thymus gland.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Breast Cancer | Malignant Breast Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Blood draw for the laboratory assessment | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- Radiation Therapy
- description
- Up to 100 Breast cancer patients receiving radiation therapy
- interventionNames
- Procedure: Blood draw for the laboratory assessment
- label
- No Radiation Therapy
- description
- Up to 25 Breast cancer patients NOT receiving radiation therapy as control
- interventionNames
- Procedure: Blood draw for the laboratory assessment
Primary outcomes (14)
- measure
- Level of signal joint T cell Receptor Exclusion Circles (sjTREC) in peripheral blood T cells
- timeFrame
- baseline
- description
- As measured by quantitative PCR in participants receiving radiotherapy (RT)
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
- Maximum age
- 50 Years
Show eligibility criteria text
Inclusion Criteria: * Women aged 18 to 50 undergoing mastectomy or breast-conserving surgery for breast cancer of any subtype at DUMC and associated satellite centers * Histologic documentation of breast cancer based on pathology * Systemic therapies including hormone therapy, targeted therapy, chemotherapy and immunotherapy as given for breast cancer treatment at the discretion of the treating medical oncologist are allowed and use of such therapies will be documented and included as a covariate * Willing and able to provide written informed consent Exclusion Criteria: * Prior history of therapeutic high-dose irradiation of the thorax (e.g. for treatment of lung cancer, head/neck cancer, Hodgkin disease, etc., not just radiological imaging alone) * History of thymectomy or treatment with immunosuppressive drugs within the past six months * Individuals with rheumatoid arthritis or other autoimmune conditions * Individuals with Down's syndrome * Male patients
References
Publications (0)
Data not yet available
No reference posted for this study.