Clinical trial · Interventional
QLESP Block for Pain Control in Robotic Partial Nephrectomy
Ultrasound-Guided L2 Level QLESP Block for Postoperative Analgesia in Robot-Assisted Partial Nephrectomy: A Prospective Randomized Controlled Trial
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 26, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260926-000001
Summary
Brief summary (as posted)
The goal of this clinical trial is to learn if an ultrasound-guided nerve block called QLESP works to reduce pain and the need for strong pain medicines after robotic kidney surgery in adults. The main questions it aims to answer are: 1. Does QLESP reduce the total amount of opioid pain medicine participants need in the first 48 hours after surgery? 2. Does QLESP lower pain scores and improve recovery quality after surgery? Researchers will compare participants who receive QLESP block to participants who receive the same numbing medicine injected only at the surgical wound sites. Participants will: 1. Be randomly assigned to receive either QLESP or local wound injection before surgery. 2. Have a patient-controlled pain pump for 48 hours after surgery. 3. Complete pain scores and recovery quality questionnaires at 2, 6, 12, 24, 48, and 72 hours after surgery. 4. Be followed until hospital discharge.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Nerve Block | — | UNRESOLVED | — |
| Postoperative Pain | — | UNRESOLVED | — |
| Renal Cell Carcinoma (Kidney Cancer) | Renal Cell Carcinoma | CURATED_BROADER | 0.80 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| ropivacaine | Drug | — | UNRESOLVED |
| ropivacaine (local infiltration) | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- QLESP Group
- description
- Participants receive ultrasound-guided QLESP block with 30 mL of 0.375% ropivacaine (15 mL in the erector spinae fascial plane and 15 mL in the quadratus lumborum-psoas major interfascial plane) after induction of general anesthesia.
- interventionNames
- Drug: ropivacaine
- type
- ACTIVE_COMPARATOR
- label
- Control Group
- description
- Participants receive local wound infiltration with 30 mL of 0.375% ropivacaine at the port sites performed by the surgeon at the end of surgery.
- interventionNames
- Drug: ropivacaine (local infiltration)
Primary outcomes (1)
- measure
- Cumulative Opioid Consumption at 48 Hours Postoperatively
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * Aged 18 to 75 years * Scheduled for elective robot-assisted partial nephrectomy (RAPN) * American Society of Anesthesiologists (ASA) physical status I to III * Body mass index (BMI) 18 to 35 kg/m² * Voluntarily signed informed consent form Able to understand pain scoring and use of patient-controlled analgesia (PCA) Exclusion Criteria: * Language, communication, or comprehension barriers * Infection at the intended puncture site * Coagulopathy or bleeding diathesis * Known allergy or contraindication to local anesthetics or opioids * Use of analgesic medications within the past 3 months * Peripheral neuropathy * Severe cardiac, hepatic, or renal dysfunction * Pregnancy or breastfeeding * Refusal to participate in the study
References
Publications (4)
- RESULTElsharkawy H, Bajracharya GR, El-Boghdadly K, Drake RL, Mariano ER. Comparing two posterior quadratus lumborum block approaches with low thoracic erector spinae plane block: an anatomic study. Reg Anesth Pain Med. 2019 Mar 28:rapm-2018-100147. doi: 10.1136/rapm-2018-100147. Online ahead of print. PMID 30923253
- RESULTKadam VR, Van Wijk RM, Ludbrook GL, Thiruvenkatarajan V. Anatomical and ultrasound description of two transmuscular quadratus lumborum block approaches at L2 level and their application in abdominal surgery. Anaesth Intensive Care. 2019 Mar;47(2):141-145. doi: 10.1177/0310057X19839931. Epub 2019 May 15. PMID 31088120
- RESULTLittle C, Rahman S. Quadratus Lumborum Blocks in Nephrectomy: A Narrative Review. Local Reg Anesth. 2021 Apr 19;14:57-65. doi: 10.2147/LRA.S290224. eCollection 2021. PMID 33907461
- RESULTHe Y, Huang M, Zhong Q, Ni H, Yu Z, Zhang X. Analgesic Effect of Ultrasound-Guided Anterior Quadratus Lumborum Block at the L2 Level in Patients Undergoing Laparoscopic Partial Nephrectomy: A Single-Center, Randomized Controlled Trial. Pain Res Manag. 2022 Dec 15;2022:8958859. doi: 10.1155/2022/8958859. eCollection 2022. PMID 36569463