Clinical trial · Observational
Preoperative 3D Magnetic Resonance Elastography for Predicting Surgical Risk in Patients Undergoing Hepatectomy
A Prospective Study on Preoperative Regional Liver Function Assessment Using Three-Dimensional Magnetic Resonance Elastography for Predicting Surgical Risk and Postoperative Liver Failure in Patients Undergoing Hepatectomy for Primary or Metastatic Liver Cancer
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
How to accurately and safely evaluate regional liver function before hepatectomy remains an important unsolved problem in the surgical management of hepatocellular carcinoma (HCC). We plan to develop a non-invasive, functional 3D-MRE-based method for preoperative regional hepatic functional reserve assessment, and to evaluate its ability to predict surgical risk and postoperative liver failure in patients with HCC undergoing hepatectomy.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Hepatic Cancer | Liver Neoplasm | PROBABILISTIC | 0.70 |
| Hepatocellular Carcinoma | Hepatocellular Carcinoma | ONTOLOGY_EXACT | 0.98 |
| Intrahepatic Cholangiocellular Carcinoma | Intrahepatic Cholangiocarcinoma | ALIAS | 0.90 |
| Metastatic Hepatocellular Carcinoma | Hepatocellular Carcinoma | CURATED_BROADER | 0.78 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Three-Dimensional Magnetic Resonance Elastography | Device | — | UNRESOLVED |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- Incidence of Post-Hepatectomy Liver Failure (PHLF)
- timeFrame
- Within 90 days after surgery
- description
- Post-hepatectomy liver failure will be defined and graded according to the International Study Group of Liver Surgery (ISGLS) criteria (Grade A/B/C), based on postoperative bilirubin and INR values.
Secondary outcomes (1)
- measure
- Correlation between preoperative 3D-MRE regional stiffness parameters and future liver remnant function
- timeFrame
- Baseline (preoperative)
- description
- Association between region-specific viscoelastic parameters (stiffness, storage modulus, loss modulus, damping ratio) and clinical liver function indices
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * Age 18-80 years * Pathologically or radiologically confirmed diagnosis of one of the following: hepatocellular carcinoma, intrahepatic cholangiocarcinoma, or liver metastasis (e.g., from colorectal cancer) * Scheduled to undergo curative hepatectomy * Child-Pugh class A or B liver function * Able to tolerate MRI examination * Provision of signed and dated informed consent Exclusion Criteria: * Contraindication to MRI (e.g., non-MRI-compatible implants, severe claustrophobia) * Child-Pugh class C liver function * Prior history of liver resection or liver transplantation * Presence of extrahepatic metastasis * Emergency surgery (e.g., due to tumor rupture) * Severe cardiopulmonary or renal dysfunction precluding surgery * Pregnant or breastfeeding women * Unwillingness or inability to comply with study procedures or follow-up
References
Publications (0)
Data not yet available