Clinical trial · Observational
A Study of Lung Cancer Risk
ARISE: Assessing Lung Cancer Risk in Never-Smoking Women
NCT07701733CI-TRIAL-00122186recruitingClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The researchers are doing this study to learn more about factors that may increase the risk of lung cancer in people who have never smoked. This information may help predict which people who have never smoked may be more likely to get lung cancer.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Lung Cancer | Malignant Lung Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Questionnaire | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- Case patients
- description
- Must have pathologically confirmed primary lung adenocarcinoma.
- interventionNames
- Other: Questionnaire
- label
- Control participants
- description
- Must have no personal history of lung cancer, symptoms suspicious for lung cancer, or suspicious pulmonary nodules.
- interventionNames
- Other: Questionnaire
Primary outcomes (1)
- measure
- Identify factors associated with the risk of NSCLC
- timeFrame
- 3 years
- description
- analyses will include all participants who completed the demographic and exposure assessment and whole-exome sequencing
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 40 Years
- Maximum age
- 74 Years
Show eligibility criteria text
Criteria: * Female at birth * Age 40-74 years * No smoking history * Participants must be never-smokers, defined as having smoked \<100 cigarettes in their lifetime * Documentation of disease - case patients o Case patients must have pathologically confirmed primary lung adenocarcinoma. New and prevalent cases will be eligible. Case patients with a history of prior non-lung cancer will be eligible for the study unless actively being diagnosed or treated for another form of cancer at the time of enrollment. * Criteria for control participants * Control participants must have no personal history of lung cancer, symptoms suspicious for lung cancer, or suspicious pulmonary nodules. Participants recruited as controls and found on imaging to have lesions suspicious for lung cancer will be excluded from analysis and followed prospectively. Data regarding these participants will be reported in a sensitivity analysis. Additional control participants will be recruited to ensure balanced age- and race-matched enrollment by frequency matching. Control participants with a history of prior non-lung cancer will be eligible for the study unless actively being diagnosed or treated for another form of cancer at the time of enrollment.
References
Publications (0)
Data not yet available
No reference posted for this study.