Clinical trial · Interventional
Electroacupuncture and Exercise for Chemotherapy-Induced Peripheral Neuropathy (CIPN)
Electro-Acupuncture Combined With Exercise for Chemotherapy-Induced Peripheral Neuropathy in Patients Receiving Taxanes or Platinum-based Agents: A Randomized Controlled Trial
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect of cancer treatment that causes numbness, pain, and balance issues in a patient's hands and feet. This study focuses on finding a non-drug approach to help cancer survivors manage these uncomfortable symptoms. The main purpose of this research is to evaluate whether combining Electroacupuncture(EA) with a exercise training program works better than using electroacupuncture alone. Electroacupuncture uses gentle electrical pulses through acupuncture needles to stimulate nerves, while the exercise program aims to improve a patient's balance, physical strength, and movement safety. Participants will be randomly assigned to receive either the combination therapy or electroacupuncture alone. The study involves scheduled hospital visits along with home-based practice guided by instructional videos. The researchers aim to evaluate the efficacy of combined EA and exercise training program on neurological symptoms and quality of life in CIPN patients across different CTCAE grades.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer | Malignant Neoplasm | ALIAS | 0.90 |
| Chemotherapy-induced Peripheral Neuropathy (CIPN) | — | UNRESOLVED | — |
Interventions
Interventions (4)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Electroacupuncture | Device | — | UNRESOLVED |
| Exercise Training | Behavioral | — | UNRESOLVED |
| General Health Education | Behavioral | — | UNRESOLVED |
| Structured Home-Based Health Education and Dose-Controlled Exercise Program | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Electroacupuncture (EA) combined with progressive exercise training
- description
- Participants in this arm receive Electroacupuncture (EA) combined with a progressive multi-modal exercise training program. The intervention frequency is explicitly tailored according to the participant's attendance tier: Tier 1 attends once weekly, while Tier 2 attends twice weekly. Each in-hospital session includes 20 minutes of EA followed by 30 minutes of progressive multi-modal exercise training. To ensure dosage consistency across both tiers, participants utilize a structured digital home-support platform via QR code videos to perform home-based exercises (Tier 1: twice weekly; Tier 2: once weekly), standardizing the total cumulative exercise volume to exactly 3 sessions per week for all participants.
- interventionNames
- Device: Electroacupuncture
- Behavioral: Exercise Training
- Behavioral: Structured Home-Based Health Education and Dose-Controlled Exercise Program
- type
- ACTIVE_COMPARATOR
- label
- EA Only
- description
- Participants in this arm receive Electro-Acupuncture (EA) alone as an active control to match the acupuncture dosage of the experimental group. The in-hospital session frequency is identical to the experimental group and dictated by the stratification tier: Tier 1 attends once weekly, and Tier 2 attends twice weekly. Each session consists of 20 minutes of identical EA treatment at the same acupoints and stimulation parameters. No progressive balance training or home-based exercise videos are provided; instead, participants receive only general oral health, environment safety, and peripheral care education from the research team.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: 1. Confirmed cancer diagnosis with prior taxane or platinum-based chemotherapy. 2. CIPN symptoms staged as CTCAE Grade 1, 2, or 3. 3. Life expectancy \> 6 months and capable of independent ambulation. Exclusion Criteria: 1. Presence of a cardiac pacemaker. 2. Severe coagulation disorders. 3. Neuropathy from other etiologies (non-chemotherapy induced).
References
Publications (0)
Data not yet available