Clinical trial · Observational
Clinicopathological Predictors of Recurrence in Papillary Thyroid Carcinoma
Clinicopathological Predictors of Recurrence in Papillary Thyroid Carcinoma: Evidence From a Large Cohort of Patients With Extended Follow-up
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The goal of this observational study is to identify demographic and clinicopathological factors associated with disease recurrence in adults with histologically confirmed papillary thyroid carcinoma (PTC) who achieved an initial disease-free status after primary treatment. The main questions it aims to answer are: Which demographic and clinicopathological characteristics are associated with an increased risk of PTC recurrence? Researchers will compare patients who developed biochemical or structural recurrence with those who remained recurrence-free to assess the prognostic role of age, sex, tumor size, histological subtype, vascular invasion, capsular invasion, gross invasion of the prethyroid strap muscles, concomitant thyroiditis, multifocality, lymph-node status, and pathological stage. As this is a retrospective study, participants will not undergo any study-specific intervention or additional procedure. Researchers will review existing demographic, surgical, pathological, treatment, and follow-up data from a prospectively maintained institutional database. Follow-up data include serial serum thyroglobulin measurements, neck ultrasonography, recurrence, and disease-specific mortality.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Papillary Thyroid Carcinoma | Thyroid Gland Papillary Carcinoma | ALIAS | 0.90 |
| Recurrence Free Survival | — | UNRESOLVED | — |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (2)
- label
- Disease-free
- description
- The disease-free group included patients who achieved an initial disease-free status after primary treatment and showed no biochemical or structural evidence of recurrence during follow-up.
- label
- With recurrence
- description
- The recurrence group included patients who achieved an initial disease-free status after primary treatment and subsequently developed documented biochemical or structural recurrence.
Primary outcomes (1)
- measure
- Recurrence
- timeFrame
- From surgery to the end of follow-up (minimum of 60 months)
- description
- biochemical or structural evidence of disease arising after the achievement of an initial disease-free status.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * histologically confirmed diagnosis of papillary thyroid carcinoma * no history of previous neck surgery * availability of complete clinical, pathological, treatment, and follow-up data; * achievement of an initial disease-free status after primary treatment * minimum follow-up of 60 months for patients who remained recurrence-free Exclusion Criteria: * histological diagnosis other than papillary thyroid carcinoma * previous neck surgery * incomplete clinical, pathological, treatment, or follow-up records * follow-up shorter than 60 months in patients without recurrence * biochemical or structural evidence of persistent disease after initial treatment
References
Publications (0)
Data not yet available