Clinical trial · Observational
PeriOperative Medicine - Metabolic Inflexibility as a Mechanism for Myocardial Injury After Non-Cardiac Surgery
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The goal of this observational study is to learn whether metabolic inflexibility, which means reduced ability of the body to switch between using fats and sugars for energy, is associated with myocardial injury after non-cardiac surgery (MINS) in adults undergoing major elective abdominal cancer surgery. The main question it aims to answer is: Does pre-operative metabolic inflexibility predict myocardial injury after non-cardiac surgery (MINS) within the first 72 hours after surgery? Participants will continue with their usual surgical care and pre-planned CPET (which can measure metabolic flexibility). As part of the study, participants will: * Have additional blood samples taken before and after surgery * Have an echocardiogram and, where possible, muscle ultrasound * Wear a wrist-worn activity monitor before surgery * Have routine clinical and surgical information collected from their medical records * Receive a follow-up phone call around 90 days after surgery
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| MINS | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Pre-operative Metabolic Inflexibility | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Major Abdominal Cancer Surgery Cohort
- description
- Adults aged 18 years and over who are scheduled to undergo major elective abdominal cancer surgery and are already referred for routine pre-operative cardiopulmonary exercise testing (CPET). This is an observational cohort study; no study-specific treatment or intervention will be assigned. Participants will continue with their usual surgical and perioperative care. The study will collect additional blood samples, imaging assessments, CPET-derived metabolic data, wearable activity data, and routine clinical information to evaluate whether pre-operative metabolic inflexibility is associated with myocardial injury after non-cardiac surgery.
- interventionNames
- Other: Pre-operative Metabolic Inflexibility
Primary outcomes (1)
- measure
- Development of Myocardial Injury after Non-Cardiac Surgery
- timeFrame
- From surgery to 72 hours post surgery
- description
- The primary outcome is the number of participants who develop myocardial injury after non-cardiac surgery (MINS) within 72 hours after surgery. MINS means evidence of heart muscle injury after an operation that is not heart surgery. It will be assessed using blood tests for high-sensitivity cardiac troponin I, a protein that is released into the blood when the heart muscle is injured. Blood samples will be taken on postoperative days 1, 2, and 3. Participants will be classified as having MINS if their postoperative troponin result is above the study-defined threshold for myocardial injury and the injury is judged to be related to the perioperative period rather than another clear non-surgical cause.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Adults aged 18 or over * Scheduled for major elective abdominal cancer surgery with planned overnight admission * Scheduled for pre-operative CPET * Able to provide written informed consent Exclusion Criteria: * Less than 18 years old * Emergency surgery * Unable or unwilling to undergo CPET * Pregnancy * Active sepsis * End-stage organ failure (e.g. on dialysis) * Participants without the mental capacity to consent * Diagnosis of Type 1 Myocardial Infarction meeting the 4th Universal Definition criteria during the immediate pre-operative period. (Note: Added based on MINS definition context)
References
Publications (0)
Data not yet available