A Real-world Study of Mirvetuximab Soravtansine (MIRV) in Ovarian Cancer Patients of Expression of Folate Receptor α（FRα）

Inclusion Criteria:

* Patients who meet all of the following inclusion criteria are eligible to participate in the study:

  1. Female patients aged ≥18 years.
  2. Patients must have histologically confirmed epithelial ovarian cancer, fallopian tube cancer, or primary peritoneal cancer.
  3. Patients must have PD on or after the most recent anti-cancer therapy.
  4. Patients must have FRα expression confirmed by VENTANA FOLR1 (≥ 25% of tumor cells with intensity ≥ 2 + after FRα staining).
  5. Patients must have normal major organ function and be suitable for MIRV monotherapy or combination therapy according to clinical recommendations
  6. Patients must have at least 1 evaluable lesion per RECIST v1.1 (radiologically assessed by the investigator).
  7. Eastern Cooperative Oncology Group Performance Status (ECOG PS) score must be 0-2.
  8. All toxicities (except alopecia) associated with prior therapy must have recovered to ≤ grade 1 per common terminology criteria for adverse events （CTCAE）v5.0.
  9. Patients must have had completed any major surgery at least 4 weeks prior to the first dose of MIRV, and have recovered or stabilized from postoperative complications of prior surgery.
  10. Patients must have expected survival of at least 12 weeks as assessed by the investigator.
  11. Patients must sign informed consent form（ICF）, and willingness and ability to comply with the study protocol, including scheduled treatment, regular follow-up, and examinations.

Exclusion Criteria:

* Patients who meet any of the following criteria may not be enrolled in the study:

  1. Participation in other clinical studies during the same period.
  2. Patient with known prior hypersensitivity to monoclonal antibody therapy or maytansinoids, or to study drug and/or any of its excipients.
  3. Patients with active or chronic corneal disorders, history of corneal transplant, or active ocular conditions requiring ongoing treatment/monitoring such as uncontrolled glaucoma, wet age-related macular degeneration requiring treatment with intravitreal injections, active diabetic retinopathy with macular edema, macular degeneration, presence of papilledema and/or monocular vision.
  4. Patients with prior treatment with MIRV or other FRα-targeting agents. (Only for patients in prospective cohort)
  5. Pregnant or breast-feeding females. Women of childbearing potential must agree to use highly effective contraception while using study drug and for at least 7 months after the last dose of MIRV.
  6. Current participation in any interventional study other than routine clinical practice.
  7. Any other condition that, in the investigator's judgment, makes the patient unsuitable for participation in this study