Clinical trial · Observational
Digital Phenotyping of Psychological Distress in Skin Cancer Patients
Digital Phenotyping of Psychological Distress in Skin Cancer Patients: A Transformer-Based Analysis of Chinese Social Media Content
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This prospective observational study enrolls 500 skin cancer patients across five Chinese tertiary care centers. The investigators use natural language processing and a hierarchical transformer model to analyse 1.2 million social media posts (Weibo, Douyin, Xiaohongshu, WeChat) for psychological distress and suicide ideation, with prospective validation of an AI Early Warning System.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Basal Cell Carcinoma of Skin | Skin Basal Cell Carcinoma | ALIAS | 0.90 |
| Melanoma (Skin Cancer) | Melanoma | ONTOLOGY_EXACT | 0.85 |
| Skin Cancer | Malignant Skin Neoplasm | ALIAS | 0.90 |
| Squamous Cell Carcinoma Head and Neck Cancer (HNSCC) | Head and Neck Squamous Cell Carcinoma | ALIAS | 0.85 |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (1)
- label
- cancer patients across five Chinese tertiary care centers
Primary outcomes (1)
- measure
- Incidence of Suicide Ideation Risk Assessed by the Columbia-Suicide Severity Rating Scale (C-SSRS)
- timeFrame
- 24 months
- description
- Proportion of participants with C-SSRS score ≥ 2 (active suicidal ideation with some intent to act, without specific plan) at any follow-up assessment. The C-SSRS is a clinician-administered instrument with a severity subscale ranging from 0 (no suicidal ideation) to 5 (active suicidal ideation with specific plan and intent). Higher scores indicate greater suicide risk.
Secondary outcomes (4)
- measure
- Depression Severity Assessed by the Patient Health Questionnaire-9 (PHQ-9)
- timeFrame
- 24 months
- description
- Mean change in PHQ-9 total score from baseline to each follow-up assessment. The PHQ-9 is a 9-item self-report questionnaire measuring depressive symptoms over the past 2 weeks. Total scores range from 0 to 27, with higher scores indicating greater depression severity (moderate-to-severe: ≥10).
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: 1. Age ≥ 18 years 2. Histologically confirmed skin cancer within the preceding 60 months 3. Active user of at least one target social media platform (Weibo, Douyin, Xiaohongshu, or WeChat Channels) 4. Willingness to provide informed consent for social media data collection 5. Ability to read and write in Chinese Exclusion Criteria: 1. Pre-existing major psychiatric disorder diagnosed prior to cancer diagnosis 2. Cognitive impairment preventing informed consent 3. Inability to access social media accounts 4. Concurrent participation in other digital mental health interventions
References
Publications (0)
Data not yet available