Clinical trial · Interventional
DEPART Study at Yale
Dupuytren's Disease Evaluation of Preventative or Adjuvant Radiation Therapy: DEPART
NCT07661342CI-TRIAL-00115389Dupuytren'snot yet recruitingPhase 3ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This is a randomized study to determine whether radiation therapy reduces the risk of progression / recurrence of Dupuytren's disease / contracture.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Dupuytren's Contracture | Palmar Fibromatosis | ALIAS | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Radiation Therapy | Radiation | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Radiation Therapy
- description
- early stage DD (no flexion contraction in affected hand) - randomized to Radiotherapy
- interventionNames
- Radiation: Radiation Therapy
- type
- NO_INTERVENTION
- label
- Standard of Care
- description
- Patients are receiving standard of care.
Primary outcomes (1)
- measure
- Number of Participants with Passive Extension Deficit (PED)
- timeFrame
- Day 0 (corresponding to the day of local treatment for intervention groups) and then at 6, 12, 24, 36, 48, 60, 84 and 108 months
- description
- Deterioration greater than 20 degrees Passive Extension Deficit (PED) in any joint(s) of any of the affected digit(s) from post-intervention baseline in the presence of a palpable cord OR instigation of salvage surgical fasciectomy (SF) or NA to any of the affected digit(s).
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 30 Years
Show eligibility criteria text
Inclusion Criteria: * English-speaking * Patient consent * No previous radiotherapy to the affected hand * No history of radiation sensitivity diseases (e.g. Scleroderma, Ataxia Telangiectasia, Li Fraumeni) * Age\>30 * Life expectancy \>5 years * Available and willing to participate in at least 5 years of follow-up * Female patients capable of child-bearing that are not pregnant Exclusion Criteria: * Pregnancy or lactation * Known genetic disease that would make them extremely sensitive to radiation therapy, e.g. Scleroderma, Ataxia Telangiectasia, Li Fraumeni
References
Publications (0)
Data not yet available
No reference posted for this study.