Clinical trial · Observational
Impact of IMA Occlusion on Anastomotic Leakage
The Effect of the Degree of Inferior Mesenteric Artery Occlusion on Anastomotic Leakage After Rectal Cancer Surgery
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Rectal cancer is primarily treated with surgery, including low anterior resection or ultra-low anterior resection depending on tumor characteristics. Anastomotic leakage is one of the most serious postoperative complications and is associated with increased morbidity and mortality. Established risk factors include male sex, preoperative radiotherapy, low anastomosis, advanced age, comorbidities, and vascular disease. Atherosclerosis may contribute to anastomotic leakage by reducing blood flow and impairing tissue perfusion at the anastomotic site. The inferior mesenteric artery (IMA), a major source of blood supply to the colorectal region, may be affected by atherosclerotic narrowing or occlusion, potentially increasing the risk of postoperative leakage. The aim of this study is to assess the degree of IMA occlusion using routine preoperative contrast-enhanced computed tomography (CT) scans obtained for rectal cancer staging and to investigate its association with anastomotic leakage after rectal cancer surgery. Identification of patients with severe IMA occlusion may help guide the selective use of protective stomas to reduce the risk of this complication.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Anastomotic Leak Rectum | — | UNRESOLVED | — |
| Inferior Mesenteric Artery | — | UNRESOLVED | — |
| Rectal Cancer Surgery | — | UNRESOLVED | — |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (2)
- label
- Group 1
- description
- Patients who underwent surgery for rectal cancer and have anastomotic leakage.
- label
- Group 2
- description
- Patients who underwent surgery for rectal cancer and did not have anastomotic leakage.
Primary outcomes (1)
- measure
- The diameter of the inferior mesenteric artery
- timeFrame
- Preoperative
- description
- The effect of the diameter of the inferior mesenteric artery on the leak rate was measured double-blindly by preoperative computed tomography.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 75 Years
Show eligibility criteria text
Inclusion Criteria: * ICD C20 Patients diagnosed with malignant neoplasm of the rectum * Patients who have undergone laparoscopic or open surgery with low anterior resection or ultra low anterior resection due to rectal cancer Exclusion Criteria: * Patients with a history of abdominal aorta surgery/grafting * Patients diagnosed with vascular, autoimmune, or rheumatological diseases.
References
Publications (0)
Data not yet available