Clinical trial · Observational
Non-Operative Management and Following Immunotherapy for Colorectal Cancer and Other GI Cancers
Non-Operative Management and Following Immunotherapy for Colorectal Cancer and Other GI Cancers (NOMIC Trial)
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This is a single-center, bidirectional (retrospective and prospective) registry study aimed at evaluating the safety and efficacy of Non-Operative Management (NOM) and Organ-Preserving Functional Surgery (OPFS) in patients with mismatch repair-deficient/microsatellite instability-high (dMMR/MSI-H) or POLE-mutated gastrointestinal (GI) cancers who received neoadjuvant immunotherapy.Patients achieving a clinical complete response (cCR) or near-cCR may undergo a "Watch \& Wait" (W\&W) strategy, while those with near-cCR or non-cCR ($\\le ymrT2N0$) may undergo local excision (LE) or endoscopic resection (ESD/EMR). Patients undergoing radical operation (RO) will serve as the control cohort to compare oncological outcomes and safety data.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal (Colon or Rectal) Cancer | Childhood Colorectal Carcinoma | ALIAS | 0.90 |
| Gastrointestinal Cancer | Malignant Digestive System Neoplasm | ALIAS | 0.90 |
| Stomach (Gastric) Cancer | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| NOM | Other | — | UNRESOLVED |
| RO | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- Experimental Cohort (NOM)
- description
- Patients achieving a clinical complete response (cCR) or near-cCR may undergo a "Watch \& Wait" (W\&W) strategy, while those with near-cCR or non-cCR (≤ymrT2N0$) may undergo local excision (LE) or endoscopic resection (ESD/EMR).
- interventionNames
- Other: NOM
- label
- Control arm
- description
- Patients undergoing radical operation (RO) will serve as the control cohort to compare oncological outcomes and safety data.
- interventionNames
- Other: RO
Primary outcomes (1)
- measure
- Organ Preservation Rate
- timeFrame
- 3 years after the completion of neoadjuvant immunotherapy.
- description
- The proportion of patients successfully managed with NOM without the need for supplementary radical surgery, loss of organ function, or a permanent stoma (specifically for rectal cancer patients).
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion Criteria: 1. Retrospective Cohort Inclusion Criteria * Pathologically confirmed gastrointestinal malignancy determined as MSI-H/dMMR or POLE mutation, and initially resectable. * Completed prior immunotherapy. * No evidence of distant metastasis. * Managed with W\&W, LE, endoscopic surgery, or radical operation after treatment. 2. Prospective Cohort Inclusion Criteria * Pathologically confirmed gastrointestinal malignancy determined as MSI-H/dMMR or POLE mutation, and initially resectable. * Eastern Cooperative Oncology Group (ECOG) performance status of 0-1. * Immunotherapy status: naive, currently receiving, or completed treatment, and evaluated by the PKUCH-NOMIC research group as cCR/near-cCR or Non-cCR (≤ ymrT2N0). * No evidence of distant metastasis. * Absence of emergencies requiring immediate surgery (e.g., hemorrhage, perforation, obstruction). Exclusion Criteria: * Recurrent gastrointestinal tumors.Initial presence of unresectable distant metastases. * Serum creatinine \> 1.5 times upper limit of normal (ULN). * History of pelvic radiation therapy.Inability to tolerate MRI examinations. * History of other malignancies within the past 5 years with a survival rate significantly lower than the historical rectal cancer survival data of this center (except adequately treated basal cell carcinoma, cutaneous squamous cell carcinoma, small renal cell carcinoma, breast cancer, and papillary thyroid carcinoma). * Arterial thromboembolic events within the past 6 months (e.g., angina, myocardial infarction, transient ischemic attack \[TIA\], cerebral vascular accident \[CVA\]). * Prior receipt of other types of investigational anti-tumor therapies. * Pregnant or lactating women. * Concomitant diseases or mental health conditions that may interfere with study participation.
References
Publications (0)
Data not yet available