Clinical trial · Interventional
Bone Defects Reconstruction After Dentigerous Cyst Enucleation With Autogenous Demineralized Dentin Matrix- ADDM and Advanced Platelet-Rich Fibrin- A-PRF.
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This prospective clinical study evaluates bone healing following dentigerous cyst enucleation associated with impacted mandibular third molar extraction. The study compares spontaneous blood clot healing, Advanced Platelet-Rich fibrin (A-PRF), and A-PRF combined with Autogenous Dentin Demineralized Matrix (ADDM). Bone healing is assessed as the primary outcome, while postoperative pain intensity assessed using the Numerical Rating Scale (NRS) with graphical representation represents a secondary outcome. The study aims to determine whether the use of A-PRF or A-PRF combined with ADDM improves postoperative healing outcomes compared with spontaneous blood clot healing.
Conditions
Conditions (10)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Autogenous Dentin Graft | — | UNRESOLVED | — |
| Bone Regeneration | — | UNRESOLVED | — |
| Demineralized Dentin Matrix | — | UNRESOLVED | — |
| Dentigerous Cyst | — | UNRESOLVED | — |
| Dentin Matrix | — | UNRESOLVED | — |
| Impacted Lower Third Molar | — | UNRESOLVED | — |
| Impacted Mandibular Third Molar | — | UNRESOLVED | — |
| Impact Molar | — | UNRESOLVED | — |
| Mandible Cyst | — | UNRESOLVED | — |
Interventions
Interventions (4)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Advanced Platelet-Rich Fibrin (A-PRF) | Biological | — | UNRESOLVED |
| Autogenous Demineralized Dentin Matrix (ADDM) | Biological | — | UNRESOLVED |
| Impacted third molar extraction | Procedure | — | UNRESOLVED |
| Mandibular dentigerous cyst enucleation | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- type
- ACTIVE_COMPARATOR
- label
- Blood Clot Healing
- description
- Healing of the postoperative defect following enucleation of mandibular dentigerous cyst associated with extraction of impacted mandibular third molar without additional regenerative biomaterials
- interventionNames
- Procedure: Impacted third molar extraction
- Procedure: Mandibular dentigerous cyst enucleation
- type
- EXPERIMENTAL
- label
- A-PRF
- description
- Application of Advanced Platelet-Rich Fibrin (A-PRF) into the postoperative defect following enucleation of mandibular dentigerous cyst associated with extraction of impacted mandibular third molar
- interventionNames
- Procedure: Impacted third molar extraction
- Biological: Advanced Platelet-Rich Fibrin (A-PRF)
- Procedure: Mandibular dentigerous cyst enucleation
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion Criteria: * Patients diagnosed with dentigerous cysts associated with impacted mandibular third molars * Indication for surgical enucleation and tooth extraction * Ability to provide informed consent * Availability for postoperative follow-up examinations and CBCT assessment Exclusion Criteria: * Acute local infection at the surgical site * Systemic diseases affecting bone healing or tissue regeneration * Immunosuppressive therapy * Pregnancy or breastfeeding * Hematological disorders affecting platelet function, coagulation, or fibrin formation (including thrombocytopenia, coagulopathies, or anticoagulant therapy). * History of radiotherapy in the head and neck region * Use of medications affecting bone metabolism * Heavy smoking * Inability to comply with follow-up visits or postoperative recommendations
References
Publications (0)
Data not yet available