PET-Enabled Dual-Energy CT in Multiple Myeloma

Inclusion Criteria:

For all research participants:

* Adults (age ≥ 18 years old)
* Ability to understand and willingness to sign an informed consent form
* Ability to adhere to the study visit schedule and other protocol requirements.
* Willing and able to fast for at least 6 hours before and for the duration of the scan
* No strenuous exercise for 24 hours prior to being scanned
* Willing to lie on the scanner bed for up to 60 minutes

For healthy volunteers only:

• Free of history of cardiovascular, inflammatory, infections or metabolic diseases that would result in changes in bone marrow.

For cancer patients only:

* Patients with multiple myeloma who are planned to receive CAR T-cell therapy with any FDA-approved product, including Idecel and Ciltacel. Patients with prior chemo-immunotherapy are permitted.
* Able to undergo bone marrow aspirate/biopsy procedure

Exclusion Criteria:

* Self-reported history of dysphoria or anxiety in closed spaces
* Body weight \>240 kg due to limitations of the scanner bed
* Pregnant or breast-feeding (due to risks of ionizing radiation; urine pregnancy test will be administered prior to start of each PET/CT session for all participants between 18 to 60 years old who are able to get pregnant, unless documented hysterectomy or bilateral ovarian removal is available)
* Blood glucose greater than 200 as assessed by fingerstick method before injection of 18F-FDG
* Concurrent or prior enrollment in a separate research study involving a PET scan performed within the last 12 months for research purposes only. That is, PET scans are not performed as part of a patient's treatment plan (e.g. standard of care, therapeutic purposes, or clinical care) and the research study did not intend to provide therapeutic benefit to the patient.
* Prisoners
* Any condition that would prevent the understanding or rendering of informed consent.
* Any comorbidity that, in the opinion of the investigator, could compromise protocol objectives.