Clinical trial · Interventional
Exercise Intervention for Chemotherapy-Induced Peripheral Neuropathy
Prevalence and Effectiveness of Exercise on Chemotherapy-induced Peripheral Neuropathy Among Oncology Patients
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Chemotherapy-induced peripheral neuropathy (CIPN) is a common adverse effect of chemotherapy that can negatively impact patients' functional status and quality of life. This study was conducted in two phases among oncology patients receiving chemotherapy at a tertiary care teaching hospital in Chennai, India. Phase I used a descriptive survey design to determine the prevalence of CIPN. Phase II employed a randomized controlled experimental design to evaluate the effectiveness of a structured exercise program in reducing CIPN symptoms among patients with mild to moderate CIPN. Eligible participants were randomly assigned to intervention and control groups. The intervention group received education and supervised exercises involving lower and upper extremity movements, while the control group received routine care. Outcomes were assessed using the Chemotherapy-Induced Peripheral Neuropathy Assessment Scale before and after a 21-day intervention period.
Conditions
Conditions (5)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Effectiveness | — | UNRESOLVED | — |
| Exercise | — | UNRESOLVED | — |
| Neuropathy | — | UNRESOLVED | — |
| Oncology | — | UNRESOLVED | — |
| Patients on Chemotherapy | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Structured exercise program for CIPN | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Experimental Arm: Structured Exercise Program
- description
- Participants received structured education regarding chemotherapy-induced peripheral neuropathy and performed a supervised exercise program involving lower and upper extremity exercises for 21 days in addition to routine care.
- interventionNames
- Behavioral: Structured exercise program for CIPN
- type
- NO_INTERVENTION
- label
- Control Arm: Routine Care
- description
- Participants received standard oncology care including consultation and medication management according to institutional protocols.
Primary outcomes (1)
- measure
- Severity of Chemotherapy-Induced Peripheral Neuropathy
- timeFrame
- Baseline and Day 21
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 78 Years
Show eligibility criteria text
Inclusion Criteria: * Age greater than 18 years * Receiving chemotherapy * Diagnosed with mild or moderate chemotherapy-induced peripheral neuropathy * Willing to participate and provide informed consent Exclusion Criteria: * Pre-existing peripheral neuropathy unrelated to chemotherapy (e.g., diabetic neuropathy). * Uncontrolled diabetes mellitus. * Significant cardiovascular disease. * Severe musculoskeletal disorders. * Contraindications to exercise, including recent surgery, bone metastases, or severe anemia. * Severe mobility limitations. * Severe mental health conditions affecting participation.
References
Publications (0)
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