Clinical trial · Observational
Prediction of Myocardial Injury After Non-Cardiac Surgery in Urologic Cancer Patients
Prediction of Myocardial Injury After Major Non-Cardiac Surgery in Patients With Urologic Cancer: A Prospective Multicenter Observational Study
NCT07634666CI-TRIAL-00119022URO-MINSrecruitingClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This prospective multicenter observational study aims to evaluate the predictive value of artificial intelligence-based analysis of preoperative 12-lead electrocardiography for myocardial injury after non-cardiac surgery (MINS) and major adverse cardiovascular events (MACE) within 30 days after surgery in patients undergoing non-cardiac surgery for urologic cancer.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Major Adverse Cardiovascular Events (MACE) | — | UNRESOLVED | — |
| Myocardial Injury After Non-cardiac Surgery | — | UNRESOLVED | — |
| Urologic Cancer | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| No intervention assigned | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Urologic cancer patients undergoing major non-cardiac surgery
- description
- Patients with urologic malignancy scheduled for major non-cardiac surgery will be prospectively enrolled and observed for perioperative myocardial injury and related outcomes.
- interventionNames
- Other: No intervention assigned
Primary outcomes (1)
- measure
- Number of Participants with Myocardial Injury After Non-Cardiac Surgery (MINS)
- timeFrame
- Intraoperative day and postoperative days 1-2 (within 3 days after surgery)
- description
- Myocardial injury after non-cardiac surgery (MINS), defined as an elevation of fourth-generation cardiac troponin T measured on the day of surgery, postoperative day 1, and postoperative day 2 (within 3 days after surgery)
Secondary outcomes (1)
- measure
- Number of Participants with 30-Day Major Adverse Cardiovascular Events (MACE)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 60 Years
Show eligibility criteria text
Inclusion Criteria: * Age ≥ 60 years * Patients scheduled for major non-cardiac surgery under general anesthesia due to urologic cancer (e.g., radical prostatectomy, radical nephrectomy, partial nephrectomy) * Patients who undergo preoperative standard 12-lead electrocardiography * Patients classified as having intermediate or higher surgical risk * Patients who can be followed for at least 30 days postoperatively * Patients who voluntarily provide written informed consent to participate in this study Exclusion Criteria: * History of major adverse cardiovascular events (MACE) within 6 months prior to surgery * Inability to obtain essential clinical information required for study participation and follow-up * Patients who are not hospitalized after surgery * Individuals deemed inappropriate for participation in the study by the investigator due to legal or psychiatric reasons
References
Publications (4)
- RESULTXie X, Hu W, Fan X, Chen H, Tang M. Interactions Between Phosphorus, Zinc, and Iron Homeostasis in Nonmycorrhizal and Mycorrhizal Plants. Front Plant Sci. 2019 Sep 26;10:1172. doi: 10.3389/fpls.2019.01172. eCollection 2019. PMID 31616454
- RESULTMatsubara M, Muraki Y, Suzuki H, Hatano N, Muraki K. Critical amino acid residues regulating TRPA1 Zn2+ response: A comparative study across species. J Biol Chem. 2024 Jun;300(6):107302. doi: 10.1016/j.jbc.2024.107302. Epub 2024 Apr 18. PMID 38642892
- RESULTHalvorsen S, Mehilli J, Cassese S, Hall TS, Abdelhamid M, Barbato E, De Hert S, de Laval I, Geisler T, Hinterbuchner L, Ibanez B, Lenarczyk R, Mansmann UR, McGreavy P, Mueller C, Muneretto C, Niessner A, Potpara TS, Ristic A, Sade LE, Schirmer H, Schupke S, Sillesen H, Skulstad H, Torracca L, Tutarel O, Van Der Meer P, Wojakowski W, Zacharowski K; ESC Scientific Document Group. 2022 ESC Guidelines on cardiovascular assessment and management of patients undergoing non-cardiac surgery. Eur Heart J. 2022 Oct 14;43(39):3826-3924. doi: 10.1093/eurheartj/ehac270. No abstract available. PMID 36017553
- RESULTZhong L, Yan K, Liu C, Xue J, Wu L, Yin F. Clinical reasoning: a young man with reversible paralysis, cerebral white matter lesions, and peripheral neuropathy. Neurology. 2012 Aug 21;79(8):e70-2. doi: 10.1212/WNL.0b013e3182661eca. No abstract available. PMID 22915180