Clinical trial · Observational
Multimodal Al for Precision Diagnosis of Esophageal Cancer
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): local ethics review
Summary
Brief summary (as posted)
This study intends to construct two multimodal deep learning models: one for the diagnosis of esophageal cancer and the prediction of invasive depth to assess suitability for endoscopic resection; the other model, based on this, classifies endoscopic non-resectable patients into different degrees of invasion to further explore the differences in the sensitivity and survival of AI-predicted benign and malignant tumors in patients' responses to NAT, thereby providing reliable decision support for precise individualized treatment. This aspect has rarely been addressed in previous studies.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Esophageal Cancer | Malignant Esophageal Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| ESD | Other | — | UNRESOLVED |
| NAT | Other | — | UNRESOLVED |
| surgery | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- label
- NAT +surgery
- interventionNames
- Other: NAT
- Other: surgery
- label
- ESD+surgery
- interventionNames
- Other: ESD
- Other: surgery
- label
- ESD
- interventionNames
- Other: ESD
Primary outcomes (2)
- measure
- Actual receipt of additional surgery
- timeFrame
- 1 week
- description
- Actual receipt of additional surgery was defined as patients who underwent subsequent radical surgical treatment after ESD based on multidisciplinary team (MDT) recommendations, clinician judgment, and patient preference.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * Age ≥18 years. * Histologically confirmed or clinically suspected esophageal squamous cell carcinoma (ESCC). * Availability of pre-treatment endoscopic images and contrast-enhanced chest/upper abdominal CT scans. * Availability of complete clinical and pathological data. * Patients who underwent endoscopic resection (ESD/EMR) or esophagectomy with pathological assessment of tumor invasion depth. * Adequate image quality for analysis. * Written informed consent (for prospective cohorts, if applicable). Exclusion Criteria: * Histology other than squamous cell carcinoma. * Prior treatment for esophageal cancer before baseline imaging, including chemotherapy, radiotherapy, immunotherapy, or endoscopic resection. * Distant metastatic disease at diagnosis. * Incomplete clinical, imaging, or pathological data. * Poor-quality CT or endoscopic images unsuitable for analysis. * History of another active malignancy within the past 5 years. * Recurrent esophageal cancer.
References
Publications (0)
Data not yet available