Clinical trial · Interventional
Study of Peripheral Neuropathy in Patients With Advanced Urothelial Cancer Treated With Enfortumab Vedotin and Pembrolizumab With Supportive Neuridase (ENDEAVOR)
ENDEAVOR Study: A Prospective Exploratory Study Describing the Course of Peripheral Neuropathy in Patients With Locally Advanced or Metastatic Urothelial Carcinoma Treated With Enfortumab Vedotin in Combination With Pembrolizumab and Supportive Neuridase
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
his prospective exploratory study aims to describe the course of peripheral neuropathy in patients with locally advanced or metastatic urothelial carcinoma treated with enfortumab vedotin in combination with pembrolizumab and receiving supportive Neuridase. Peripheral neuropathy is a common adverse event associated with enfortumab vedotin and may negatively affect treatment tolerability, quality of life, and treatment continuation. Neuridase is a non-pharmacological supportive product intended to support peripheral nervous system function; however, its role in this clinical setting has not yet been established. Participants enrolled in this single-arm study will receive standard-of-care treatment with enfortumab vedotin plus pembrolizumab, together with supportive Neuridase according to clinical practice. The study will prospectively assess neuropathy symptoms and severity using clinical evaluations and patient-reported outcome measures, including quality-of-life questionnaires, over the course of treatment. The objective of the study is to explore neuropathy patterns and treatment tolerability in this patient population.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Peripheral Nerve Disease | — | UNRESOLVED | — |
| Urothelial Carcinoma (UC) | Urothelial Carcinoma | ONTOLOGY_EXACT | 0.85 |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| enfortumab vedotin (EV) | Drug | Enfortumab Vedotin | ALIAS |
| Neuridase | Other | — | UNRESOLVED |
| PEMBROLIZUMAB (alone or when added to a regimen above) | Drug | Pembrolizumab | ALIAS |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- arm label
- description
- Neuridase: Participants with locally advanced or metastatic urothelial carcinoma will receive standard-of-care enfortumab vedotin in combination with pembrolizumab together with supportive Neuridase according to the study protocol. Peripheral neuropathy symptoms, treatment tolerability, and patient-reported outcomes will be prospectively assessed during treatment.
- interventionNames
- Drug: enfortumab vedotin (EV)
- Drug: PEMBROLIZUMAB (alone or when added to a regimen above)
- Other: Neuridase
Primary outcomes (1)
- measure
- Incidence and Severity of Peripheral Neuropathy
- timeFrame
- From baseline to 6 months after treatment initiation
- description
- Incidence and severity of peripheral neuropathy will be prospectively assessed according to clinical evaluation and CTCAE criteria in patients receiving enfortumab vedotin plus pembrolizumab with supportive Neuridase.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
IInclusion Criteria: * Age ≥18 years * Histologically confirmed locally advanced or metastatic urothelial carcinoma * Candidate for treatment with enfortumab vedotin in combination with pembrolizumab according to clinical practice * Ability to provide written informed consent * Adequate clinical conditions to participate in the study according to investigator judgment Exclusion Criteria: * Pre-existing severe peripheral neuropathy that may interfere with study assessments * Contraindications to enfortumab vedotin or pembrolizumab according to clinical practice * Known hypersensitivity to components of Neuridase * Pregnancy or breastfeeding * Any medical, psychiatric, or social condition that, in the investigator's judgment, may interfere with study participation or interpretation of results
References
Publications (0)
Data not yet available