Clinical trial · Interventional
Laparoscopic Versus Open Radical Hysterectomy in Early-Stage Cervical Cancer
Radical Laparoscopic-assisted Hysterectomy Versus Open Radical Hysterectomy in Early-Stage Cervical Cancer: A Comparative Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The study aims to compare laparoscopic-assisted radical hysterectomy with open radical hysterectomy in women with early-stage cervical cancer. A total of 60 patients diagnosed with FIGO stage IA1, IA2, and IB1 cervical cancer were enrolled and randomly assigned into two equal groups: laparoscopic surgery and open surgery. All patients underwent total hysterectomy, bilateral adnexectomy, and pelvic lymph node dissection. Perioperative outcomes were evaluated, including operative time, blood loss, complications, and hospital stay, as well as long-term oncological outcomes such as recurrence, recurrence-free survival, and overall survival. Patients were followed for up to three years postoperatively. The findings of this study aim to assess the safety, feasibility, and clinical effectiveness of laparoscopic-assisted surgery compared with the conventional open approach in the management of early-stage cervical cancer.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cervical Cancer | Malignant Cervical Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Laparoscopic Radical Hysterectomy | Procedure | — | UNRESOLVED |
| Open Radical Hysterectomy | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Laparoscopic Radical Hysterectomy
- description
- In this study, participants underwent radical hysterectomy with bilateral adnexectomy and lymph node dissection using a laparoscopic approach, and vaginal stump closure using an endoscopic stapler was performed.
- interventionNames
- Procedure: Laparoscopic Radical Hysterectomy
- type
- ACTIVE_COMPARATOR
- label
- Open Radical Hysterectomy
- description
- Under conventional surgical techniques in this group , participants underwent open abdominal radical hysterectomy with bilateral adnexectomy and dissection of pelvic lymph nodes.
- interventionNames
- Procedure: Open Radical Hysterectomy
Primary outcomes (3)
- measure
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 38 Years
- Maximum age
- 65 Years
Show eligibility criteria text
Inclusion Criteria: * FIGO stage IA1, IA2, IB1 * patients with a tumor size \< 2 cm by MRI or pathological assessment after conization * tumours with histopathological subtypes: squamous cell carcinoma, adenocarcinoma and adeno-squamous carcinoma ( * patients with adequate; hematopoietic, renal and liver functions: * patients with BMI \< 35 ( * patients with age range 38 - 65 years old. Exclusion Criteria: * patients with mental, heart, bladder, liver, or kidney illness * patients who had received pre-operative chemotherapy or radiotherapy pregnant patients * patients with incomplete data or lost follow-up * patients with radiological evidence of invasion of the outer 1/3 of the cervical stroma or the lower uterine segment.
References
Publications (0)
Data not yet available