Clinical trial · Interventional
Increasing Uptake of Cascade Testing in Families With Familial Cancer Syndromes: A Randomized Controlled Trial of a Registry-aided Model.
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study is to compare the uptake rates of a patient-initiated model of cascade testing with a registry-aided model amongst relatives of patients identified to have a particular cancer predisposition gene. Cascade testing allows the benefits of genetic testing to spread beyond the patient and enables other family members to make an informed choice on genetic testing. The researcher team hopes to study the rates of cascade testing using the two models, while concurrently comparing the adherence of identified carriers to risk management recommendations, including surveillance imaging and/or prophylactic surgeries. The team also aims to understand the willingness, acceptability and barriers of a registry-aided model.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Hereditary Cancer Syndromes | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Combination of the proband-dependent approach with additional registry-aided testing reminders | Other | — | UNRESOLVED |
| Proband-dependent approach | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- OTHER
- label
- Control arm: Proband-dependent approach
- description
- The conventional approach to cascade testing whereby probands are advised to relay their genetic information to relatives and encourage them to see a genetic counsellor for discussion on predictive genetic testing. Family letters are given to probands to help disseminate this information.
- interventionNames
- Other: Proband-dependent approach
- type
- EXPERIMENTAL
- label
- Proband-dependent with registry-reminders approach
- description
- A registry-aided outreach to family members of probands to bypass the barriers inherent with the proband-dependent approach.
- interventionNames
- Other: Combination of the proband-dependent approach with additional registry-aided testing reminders
Primary outcomes (1)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 21 Years
- Maximum age
- 99 Years
Show eligibility criteria text
Inclusion Criteria: Probands: * Patients who undergo clinical genetic testing and seen at the Cancer Genetics Service (CGS) in National Cancer Centre Singapore * Pathogenic variant/ likely pathogenic variant (PV/LPV) identified in a cancer predisposition gene * Aged 21 years old and over * Singapore citizen or permanent resident ARRs: * ARRs of a proband * Aged 21 years old and over * Singapore citizen or permanent resident Exclusion Criteria: * Lacks capacity to consent * Not living in Singapore * Probands who decline to share relatives' contact details * Probands with no contactable relatives in Singapore
References
Publications (0)
Data not yet available