Clinical trial · Interventional
Letrozole vs. Clomiphene Citrate Plus Tamoxifen for Ovulation Induction and Pregnancy Outcomes.
Letrozole Versus Clomiphene Citrate Plus Tamoxifen for Ovulation Induction and Pregnancy Outcomes in Infertile Women: A Randomized Clinical Trial
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Infertility is a common reproductive health problem. Ovulation induction is a key treatment for women with anovulatory infertility. Letrozole and clomiphene citrate are widely used medications for ovulation induction. Tamoxifen has also been used as an alternative or adjunct therapy. This randomized clinical trial aims to compare the effectiveness of letrozole versus clomiphene citrate combined with tamoxifen for ovulation induction and pregnancy outcomes in infertile women. The outcomes include ovulation rate, pregnancy rate, endometrial thickness, follicular development, Miscarriage rate, and Live birth rate. The study will be conducted at Al-Thawra Hospital in Sana'a, Yemen, under the supervision of Sana'a University. Keywords: Infertility, Ovulation Induction, Letrozole, Clomiphene Citrate, Tamoxifen
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Infertility Drugs | — | UNRESOLVED | — |
| Infertility Involuntary | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Clomiphene Citrate + Tamoxifen | Drug | — | UNRESOLVED |
| Letrozole | Drug | Letrozole | ALIAS |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Letrazole Group
- description
- Participants receive letrazole for ovulation induction according to the study protocol and are followed to evaluate ovulation and pregnancy outcomes.
- interventionNames
- Drug: Letrozole
- type
- EXPERIMENTAL
- label
- Clomiphene Citrate + Tamoxifen
- description
- Participants receive Clomiphene citrate and tamoxifen for ovulatory induction according to the study protocol and are followed to assess ovulatory and pregnancy outcomes.
- interventionNames
- Drug: Clomiphene Citrate + Tamoxifen
Primary outcomes (1)
- measure
- Ovulation rate
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
- Maximum age
- 40 Years
Show eligibility criteria text
Inclusion Criteria: * Women aged between 18 and 40 years. * Patients with anovulatory polycystic ovaries. * Presence of a normal uterus and patent fallopian tubes, as confirmed by hysterosalpingography (HSG). * Husband's semen analysis within normal parameters. * Normal serum prolactin and thyroid-stimulating hormone (TSH) levels. Exclusion Criteria: * Spontaneous pregnancy. * Women with hyperprolactinemia or thyroid dysfunction. * Active liver disease or renal disease. * Documented pelvic diseases such as endometriosis, ovarian pathology, hydro- or pyosalpinx, or uterine fibroids. * Previous history of ovarian drilling. * Contraindications to letrozole, clomiphene citrate, or tamoxifen. * History of hypersensitivity reactions to study medications.
References
Publications (0)
Data not yet available