Clinical trial · Interventional
MCT Enteral Feeding to Reduce Chyle Leak After Oesophagectomy
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Chyle leak (chylothorax) is a recognised complication following minimally invasive oesophagectomy for oesophageal cancer and may result in prolonged hospital stay, nutritional compromise, and need for additional interventions. Medium-chain triglyceride (MCT) feeds reduce lymphatic flow as they are absorbed directly via the portal circulation rather than through the thoracic duct. While MCT feeds are commonly used in the management of established chyle leaks, their role in prevention has not been evaluated in a randomised controlled trial. This single-centre randomised controlled trial will evaluate whether initiating postoperative jejunostomy feeding with MCT-based enteral nutrition reduces the incidence of clinically and biochemically confirmed chyle leak compared with standard enteral feeding in patients undergoing minimally invasive or robotic-assisted oesophagectomy. Participants will be randomised in a 1:1 ratio to receive either MCT-based feeds or standard jejunostomy feeds starting on postoperative day 1. The primary outcome is the incidence of chylothorax. Secondary outcomes include chest drain output, re-intervention rates, and length of hospital stay.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Oesphageal Cancer | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| MCT-Based Jejunostomy Feed (Nutrison Peptisorb) | Other | — | UNRESOLVED |
| Standard Jejunostomy Feed (Nutrison Protein Plus) | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Standard Jejunostomy Feeding
- description
- Participants randomised to this group will receive standard postoperative enteral nutrition via feeding jejunostomy beginning on postoperative day 1. The standard formula used will be Nutrison Protein Plus 1.25 kcal/ml. Feed initiation and escalation will follow the institution's established enhanced recovery protocol.
- interventionNames
- Other: Standard Jejunostomy Feed (Nutrison Protein Plus)
- type
- EXPERIMENTAL
- label
- Medium-Chain Triglyceride (MCT) Jejunostomy Feeding
- description
- Participants randomised to this group will receive medium-chain triglyceride (MCT)-based enteral nutrition via feeding jejunostomy beginning on postoperative day 1. The formula used will be Nutrison Peptisorb 1 kcal/ml. Feed initiation and escalation will follow the same protocol as the control group.
- interventionNames
- Other: MCT-Based Jejunostomy Feed (Nutrison Peptisorb)
Primary outcomes (1)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Age ≥ 18 years * Diagnosis of oesophageal cancer (adenocarcinoma or squamous cell carcinoma) * Planned minimally invasive or robotic-assisted oesophagectomy (MIO or RAMIO) with curative intent * Placement of feeding jejunostomy at or prior to oesophagectomy * Able to provide written informed consent Exclusion Criteria: * Inability to provide informed consent * No feeding jejunostomy placed at or prior to surgery * Prior or concomitant malignancy that would interfere with study protocol or outcomes
References
Publications (0)
Data not yet available