Clinical trial · Interventional
Inflammatory Response in Children Suffering From Tethered Cord
Study of Inflammatory Response in Children Suffering From Tethered Cord
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Embryologic phenomenons that lead to dysraphisms are known, but pathophysiology remains questioned. It is supposed not to be a simple mechanistic dysfunction, and other biological phenomenons are implied in spinal cord damaging. Two main hypothesis are that manual deformation of the cells and mitochondrial membranes lead to energy deficiency and blood flow changes. On the other hand, considering traumatic spinal cord injuries (SCI), inflammation has been shown to have dramatic effects on spinal cord function and physiology. Indeed, all essays about SCI have demonstrated that the initial trauma leads to mechanical injury to cells, accompanied by damages of microvasculature, initiation of pro-apoptotic signaling and ischemia. Therefore, we could imagine that similar inflammatory processes can be implied in stretched spinal cord. In our review of literature, we found few papers highlighting the question of inflammation and CSF sampling.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Tethered Spinal Cord, Including Thickened Filum, Lipomas, Myelomeningocele and Meningocele | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| CSF sampling during surgery | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- all patients who are to undergo surgery for tethered spinal cord
- description
- Experimental group: all patients who are to undergo surgery for tethered spinal cord, including thickened filum, lipomas, myelomeningocele and meningocele
- interventionNames
- Procedure: CSF sampling during surgery
Primary outcomes (1)
- measure
- To describe the markers of chronic inflammation present in CSF collected at the beginning of surgery in children with attached low marrow.
- timeFrame
- at the beginning of surgery
- description
- Proportion of patients with the presence of at least one marker of inflammation present in CSF collected at the beginning of surgery.
Secondary outcomes (5)
- measure
- Proportion of patients with the presence of at least one marker of inflammation present in the CSF collected at the end of surgery.
Eligibility
Eligibility (as posted)
- Sex
- All
- Maximum age
- 17 Years
Show eligibility criteria text
Inclusion Criteria: * Infants and children under 18 years of age * Carriers of an attached marrow: lipomatous fiilum, meningocele, myelomeningocele, myelolipoma, * Consent of the child's parents, * Socially insured patient, * Patient willing to comply with all study procedures and duration, Exclusion Criteria: * Patients over 18 years of age, * Chronic inflammatory disease, * Ongoing anti-inflammatory treatments, * No parental consent,
References
Publications (0)
Data not yet available