Clinical trial · Observational
Clinical, Oncologic, and Metabolic Effects of Pancreatic Mass Loss After Pancreatectomy in Non-Diabetic Patients
Clinical, Oncologic, and Metabolic Effects of Pancreatic Mass Loss Following Partial, Near-Total, and Total Pancreatectomy in Patients Without Diabetes at Baseline: A Monocentric Ambispective Observational Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study will examine how removal of part or all of the pancreas affects blood sugar control, metabolism, and clinical outcomes over time. The study will include adults without diabetes before surgery who undergo pancreatic surgery as part of routine clinical care at Fondazione Policlinico Universitario A. Gemelli IRCCS. Researchers will study whether participants develop diabetes after surgery and whether this risk changes according to the type of pancreatic resection. Information from routine clinical care, metabolic tests, imaging, and pancreatic tissue samples collected during surgery may be used for research analyses.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Diabetes Mellitus Type 2 | — | UNRESOLVED | — |
| Pancreatectomy | — | UNRESOLVED | — |
| Pancreatic Neoplasms | Pancreatic Neoplasm | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (3)
- label
- Prospective Cohort
- description
- Prospectively enrolled adult patients without diabetes at baseline undergoing partial, near-total, or total pancreatectomy at the study center.
- label
- Retrospective Cohort
- description
- Retrospective cohort of adult patients without diabetes at baseline who underwent pancreatic surgery at the study center.
- label
- Ambispective Cohort
- description
- Patients without diabetes at baseline with retrospective baseline data and prospective postoperative follow-up after pancreatic surgery.
Primary outcomes (1)
- measure
- Incidence of New-Onset Diabetes Mellitus After Pancreatectomy
- timeFrame
- Within 12 months after surgery
- description
- Incidence of new-onset diabetes mellitus in participants without diabetes at baseline according to the type of pancreatic resection.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Adult patients (≥18 years) * No diabetes mellitus at baseline * Undergoing partial, near-total, or total pancreatectomy at the study center * Availability of clinical and metabolic data according to study component * Written informed consent for the prospective component Exclusion Criteria: * Diabetes mellitus at baseline * Age \<18 years * Missing key clinical data precluding eligibility assessment or primary outcome evaluation * Refusal or inability to provide informed consent for the prospective component, where applicable
References
Publications (0)
Data not yet available