Clinical trial · Observational
Multicenter Prospective Study on MRI AI Model for Midline Glioma Subtyping and Prognosis:
Application of MRI-Based Artificial Intelligence Models for Preoperative Molecular Subtyping and Prognostic Assessment of Midline Gliomas: A Multicenter Prospective Clinical Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
A vision-language model using preoperative MRI and clinical variables has been developed to simultaneously predict three key molecular markers in midline gliomas: H3K27M, IDH, and 1p/19q. This prospective multicenter study will validate the model's accuracy in preoperative molecular subtyping and its value in prognostic assessment and clinical decision-making across multiple neurosurgical centers.
Conditions
Conditions (6)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Glioma, Diffuse Midline, H3K27M-mutant | Glioma | ONTOLOGY_EXACT | 0.85 |
| Glioma Glioblastoma Multiforme | — | UNRESOLVED | — |
| Glioma of Brainstem | Brain Stem Glioma | ALIAS | 0.90 |
| Glioma : Oligodendroglioma or Astrocytoma | — | UNRESOLVED | — |
| Gliomas | Glioma | ALIAS | 0.90 |
| Gliomas Harboring IDH1 and/or IDH2 Mutations | — | UNRESOLVED | — |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- Diagnostic accuracy for midline glioma molecular subtypes
- timeFrame
- Perioperative
- description
- Model predictions compared with postoperative histopathology and molecular testing (gold standard). Performance metrics include AUC, F1 score, sensitivity, specificity, and accuracy.
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion Criteria: * Patients with diffuse gliomas were pathologically and molecularly diagnosed. * The clinical case data of all patients were complete. * Patients underwent preoperative MRI examination. Exclusion Criteria: * The tumor is not located in the intracranial midline. * Cases in which MRI were incomplete or with significant noise and artifacts.
References
Publications (0)
Data not yet available