Clinical trial · Interventional
Combined Oral and Parenteral Nutritional Therapy After Gastrectomy for Gastric Cancer
Bridging the Postoperative Nutritional Gap After Gastrectomy for Gastric Cancer: A Prospective Randomized Trial of Combined Oral and Parenteral Nutritional Therapy
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Patients undergoing gastrectomy for gastric cancer frequently experience insufficient oral intake during the postoperative recovery period because of reduced gastric capacity, early satiety, and gastrointestinal symptoms. Although oral nutritional supplements (ONS) are commonly recommended, adherence is often poor, resulting in a postoperative nutritional gap. This prospective randomized clinical trial was designed to evaluate the impact of combined oral and parenteral nutritional therapy on nutritional status and recovery after gastrectomy for gastric cancer. Patients were randomized to either a combined nutritional therapy group receiving oral nutritional supplementation plus parenteral nutrition or a control group receiving standard postoperative care. The primary endpoint was postoperative body weight change at 4 weeks after surgery. Secondary endpoints included body composition, nutritional intake, inflammatory and immune markers, laboratory parameters, and quality of life outcomes.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Gastric Cancer (GC) | Malignant Gastric Neoplasm | CURATED_BROADER | 0.80 |
| Malnutitrion | — | UNRESOLVED | — |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Oral Nutritional Supplementation | Dietary Supplement | — | UNRESOLVED |
| Parenteral Nutrition | Other | — | UNRESOLVED |
| Standard Postoperative Nutritional Care | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Combined Nutritional Therapy
- description
- Patients received combined oral nutritional supplementation and parenteral nutritional support during the postoperative recovery period after gastrectomy for gastric cancer.
- interventionNames
- Dietary Supplement: Oral Nutritional Supplementation
- Other: Parenteral Nutrition
- type
- ACTIVE_COMPARATOR
- label
- Standard Postoperative Care
- description
- Patients received standard postoperative nutritional management according to institutional clinical pathways after gastrectomy for gastric cancer.
- interventionNames
- Other: Standard Postoperative Nutritional Care
Primary outcomes (1)
- measure
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 20 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * Age 20 to 80 years * Histologically confirmed gastric cancer * Scheduled for curative total or subtotal gastrectomy * Ability to tolerate oral intake * Residence within areas covered by home care services * Written informed consent Exclusion Criteria: * Body mass index (BMI) ≥30 kg/m² or \<18.5 kg/m² * Uncontrolled diabetes mellitus * Severe hepatic or renal dysfunction * Active malignancy other than gastric cancer * Previous chemotherapy or radiotherapy * Allergy to oral nutritional supplement products
References
Publications (0)
Data not yet available