Clinical trial · Interventional
The Association Between Bilateral Intermediate Cervical Plexus Block During Total Thyroidectomy and Surgical Stress Response
The Association Between Bilateral Intermediate Cervical Plexus Block and Salivary and Serum Biomarkers of Surgical Stress Response During Total Thyroidectomy
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The aim of this study is to determine the impact of ultrasound-guided bilateral intermediate cervical plexus block on the surgical stress response in patients undergoing total thyroidectomy, as measured by the concentration of stress and inflammatory biomarkers in the participants' saliva and serum. The study will be conducted on 48 subjects divided into two groups of 24: a control group receiving total intravenous anesthesia (TIVA) and an experimental group receiving TIVA combined with a bilateral intermediate cervical plexus block. Investigators hypothesized that a combination of bilateral intermediate cervical plexus block and total intravenous anesthesia (TIVA) would reduce the surgical stress response, as measured by salivary and blood biomarkers, compared to TIVA alone in patients undergoing total thyroidectomy. Should the research confirm the hypothesis, it will provide an objective scientific argument for including the block in standard anesthetic protocols for total thyroidectomy surgeries, with the ultimate goal of reducing the surgical stress response and ensuring faster patient recovery.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Hyperthyreosis and Goiter | — | UNRESOLVED | — |
| Surgical Stress Response | — | UNRESOLVED | — |
| Thyroid and Parathyroid Surgery | — | UNRESOLVED | — |
| Thyroid Cancer | Malignant Thyroid Gland Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| bilateral ultrasound guided intermediate cervical plexus block with 0,25% levobupivacaine | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- NO_INTERVENTION
- label
- total intravenous anesthesia (TIVA)
- type
- EXPERIMENTAL
- label
- TIVA + bilateral intermediate cervical plexus block with 0.25% levobupivacaine
- interventionNames
- Other: bilateral ultrasound guided intermediate cervical plexus block with 0,25% levobupivacaine
Primary outcomes (9)
- measure
- Serum Cortisol Concentration
- timeFrame
- Preoperative baseline, 1 hour postoperative, 24 hours postoperative and 48 hours postoperative
- description
- Assessment of serum cortisol concentration as a biomarker of surgical stress response in patents undergoing total thyroidectomy with or without intermediate cervical plexus block combined with total intravenous anesthesia. Unit of measure: nmol/L
- measure
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * patienets of both sexes * 18 years of age and older * ASA I or ASA II * euthyroid status * signed informed consent Exclusion Criteria: * patients who refuse to sign the informed consent form * infection at the block injection site * hypersensitivity or contraindications to the medications used in the study * hypothyroidism or hyperthyroidism at the time of surgery * presence of substernal goiter * additional surgical interventions during the procedure * history of previous neck surgery or radiation * coagulopathy * uncontrolled respiratory disease * diabetes mellitus * autoimmune disease * chronic corticosteroid therapy * smokers * pregnant women.
References
Publications (0)
Data not yet available