Clinical trial · Observational
Diagnostic Performance and Quantitative Analysis of [18F]FET PET in Brain Tumours
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This is a retrospective study encompassing all \[18F\]FET PET scans performed at our centre. By analysing both static and dynamic scans, conducting in-depth kinetic modelling, and comparing quantitative parameters across different tumour types and clinical contexts, the study aims to determine the true diagnostic value of \[18F\]FET PET in everyday clinical practice. The ultimate goal is to identify imaging biomarkers useful for improving tumour characterisation and distinguishing recurrence from post-treatment changes, thereby strengthening the role of \[18F\]FET PET in modern neuro-oncology.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Brain Tumors | Brain Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (1)
- label
- Patients with brain tumors
- description
- Patients with gliomas, brain metastases and meningiomas
Primary outcomes (1)
- measure
- Primary outcome
- timeFrame
- Retrospective analysis of data acquired up to December 31, 2025.
- description
- Diagnostic accuracy of \[18F\]FET PET (static and dynamic PET/CT or PET/MR) in differentiating tumor recurrence from treatment-related changes, using a composite reference standard including histopathological data (when available) and clinical-radiological follow-up.
Secondary outcomes (5)
- measure
- Secondary Outcome Measure
- timeFrame
- Up to December 31, 2025.
- description
- Quantification and clinical utility of static \[18F\]FET PET parameters in tumor characterization.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Patients who underwent a brain PET/CT or PET/MRI scan with \[18F\]FET for clinical reasons during the study period. * Age ≥ 18 years. * Indication for the scan related to diagnosis, grading, assessment of treatment response or suspected recurrence of any brain tumour (primary or metastatic). * Availability of the corresponding static and dynamic images. * Signed informed consent. Exclusion Criteria: * . Pregnancy or breastfeeding
References
Publications (0)
Data not yet available