Clinical trial · Observational
Agreement Between Large Language Model-Generated Treatment Recommendations With Guideline-Based and Tumor Board Decisions in Gastrointestinal Cancer
Concordance of Large Language Model-Generated Treatment Recommendations With Multidisciplinary Tumor Board and Guideline-Based Decisions in Gastrointestinal Cancer: A Retrospective Cohort Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The goal of this observational study is to learn whether a computer program can suggest cancer treatments that match expert recommendations for people with gastrointestinal cancer (cancer of the pancreas, stomach, or colon and rectum). The main questions it aims to answer are: * Do the treatment suggestions from the computer program match current medical guidelines? * Do these suggestions match decisions made by a multidisciplinary tumor board (a team of cancer specialists)? Researchers will review existing medical records from people who have already been treated for these cancers. They will enter key clinical information into a computer program that uses artificial intelligence (AI). The program will generate treatment suggestions for each case. Researchers will then compare these suggestions with: * guideline-based treatment recommendations * decisions made by the tumor board This study will help researchers understand whether AI tools could support doctors in making cancer treatment decisions in the future.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal Cancer | Malignant Colorectal Neoplasm | CURATED_BROADER | 0.80 |
| Gastric Cancer (GC) | Malignant Gastric Neoplasm | CURATED_BROADER | 0.80 |
| Pancreatic Cancer | Malignant Pancreatic Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Treatment recommendation according to official German cancer guideline | Other | — | UNRESOLVED |
| Treatment recommendation of a LLM | Other | — | UNRESOLVED |
| Treatment recommendation of a multidisciplinary tumor board | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- label
- Pancreatic cancer
- description
- Patients with pancreatic cancer
- interventionNames
- Other: Treatment recommendation according to official German cancer guideline
- Other: Treatment recommendation of a LLM
- Other: Treatment recommendation of a multidisciplinary tumor board
- label
- Gastric cancer
- description
- Patients with gastric cancer
- interventionNames
- Other: Treatment recommendation according to official German cancer guideline
- Other: Treatment recommendation of a LLM
- Other: Treatment recommendation of a multidisciplinary tumor board
- label
- Colorectal cancer
- description
- Patients with colorectal cancer
- interventionNames
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Histologically confirmed pancreatic, gastric, or colorectal adenocarcinoma * Treatment discussed in a multidisciplinary tumor board Exclusion Criteria: * Non-adenocarcinoma histology
References
Publications (0)
Data not yet available