Clinical trial · Interventional
HERO-UTUC: Intravesical RC48 After RNU for HER2+ UTUC
A Prospective Phase II Study of Single Postoperative Intravesical Disitamab Vedotin to Prevent Bladder Recurrence After Radical Nephroureterectomy in HER2-Positive Upper Tract Urothelial Carcinoma
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This is a prospective, single-center, single-arm phase II study evaluating whether a single postoperative intravesical instillation of disitamab vedotin (RC48) can reduce bladder recurrence after radical nephroureterectomy (RNU) in patients with HER2-positive upper tract urothelial carcinoma (UTUC). Eligible patients will receive one intravesical instillation of RC48 within 96 hours after surgery. The primary objective is to determine the 12-month intravesical recurrence rate. Serial urine samples will be prospectively collected to evaluate urinary methylation biomarkers for early recurrence detection.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Upper Urinary Tract Urothelial Carcinoma | Renal Pelvis and Ureter Urothelial Carcinoma | ALIAS | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Drug: Disitamab Vedotin | Drug | Disitamab Vedotin | ALIAS |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Intravesical Disitamab Vedotin Participants will receive a single postoperative intravesical instill
- description
- Participants will receive a single postoperative intravesical instillation of 180mg disitamab vedotin within 96 hours after radical nephroureterectomy.
- interventionNames
- Drug: Drug: Disitamab Vedotin
Primary outcomes (1)
- measure
- 12-Month Intravesical Recurrence Rate
- timeFrame
- 12 months
- description
- Proportion of participants with histologically confirmed bladder urothelial recurrence within 12 months after radical nephroureterectomy.
Secondary outcomes (5)
- measure
- Intravesical Recurrence-Free Survival (IVRFS)
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 85 Years
Show eligibility criteria text
Inclusion Criteria: 1. Age ≥18 years. 2. Histologically or radiologically suspected UTUC planned for RNU 3. HER2-positive tumor defined as IHC 1+, 2+, or 3+ on preoperative or surgical specimen testing. 4. ECOG performance status 0-1. 5. No prior or concomitant bladder urothelial carcinoma within 5 years. 6. Adequate hematologic, hepatic, and renal function. 7. Ability to comply with protocol-required surveillance. 8. Written informed consent. - Exclusion Criteria: 1.Evidence of metastatic disease before enrollment. 2.Prior treatment with disitamab vedotin. 3.Prior intravesical anti-cancer therapy within 12 months. 4.Active uncontrolled infection. 5.Pregnancy or breastfeeding. 6.Severe uncontrolled cardiovascular, pulmonary, hepatic, or systemic disease. 7.Known hypersensitivity to study drug components. 8.Any condition that, in the investigator's judgment, would compromise participation or interpretation. \-
References
Publications (0)
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