Clinical trial · Observational
Pregnancy Outcomes After Breast Cancer in Young Women With Germline Pathogenic Variants in Genes Other Than BRCA
Retrospective Observational Study on the Prognostic Impact of Pregnancy in Young Women With Breast Cancer Harboring a Germline Pathogenic Variant in Breast Cancer-related Genes Other Than BRCA1/2: the "Beyond BRCA BCY Collaboration"
NCT07591532CI-TRIAL-00111756Beyond BCYnot yet recruitingClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The present study aims to refine the understanding of the prognostic impact of pregnancy after breast cancer in young women harboring germline pathogenic variants in breast cancer susceptibility genes other than BRCA
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Breast Cancer | Malignant Breast Neoplasm | CURATED_EXACT | 0.92 |
| Breast Cancer and Pregnancy | — | UNRESOLVED | — |
Interventions
Interventions (0)
Data not yet available
No intervention recorded.
Design
Arms and outcomes
Arms (2)
- label
- Pregnant cohort
- description
- Women with one or more pregnancies any time after breast cancer diagnosis
- label
- Non-pregnant cohort
- description
- Women with no subsequent pregnancies after breast cancer diagnosis
Primary outcomes (2)
- measure
- Cumulative Incidence of Pregnancy After Breast Cancer Diagnosis
- timeFrame
- Up to 20 years from breast cancer diagnosis
- measure
- Invasive Disease-Free Survival (iDFS)
- timeFrame
- Up to 20 years from breast cancer diagnosis
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
- Maximum age
- 40 Years
Show eligibility criteria text
Inclusion Criteria: * Diagnosis of stage I-III invasive breast cancer between January 2000 and December 2025 * Age at breast cancer diagnosis ≤40 years * Germline pathogenic variant in at least one of the following breast cancer susceptibility genes other than BRCA: TP53, PALB2, PTEN, CDH1, STK11, CHEK2, ATM, BARD1, RAD51C, or RAD51D Exclusion Criteria: * Known germline pathogenic variant in breast cancer susceptibility genes without a diagnosis of invasive breast cancer * Diagnosis of ovarian cancer or other malignancies without a prior history of invasive breast cancer * Diagnosis of invasive breast cancer with germline variants of uncertain significance in breast cancer susceptibility genes * De novo stage IV breast cancer
References
Publications (0)
Data not yet available
No reference posted for this study.