Clinical trial · Observational
Safety and Efficacy of Vertebral Body-Sparing Craniospinal Irradiation With Proton Therapy in Pediatric Tumors
Safety and Efficacy of Vertebral Body-Sparing Craniospinal Irradiation (VBS-CSI) With Proton Therapy in Pediatric Tumors: A Single-Center Prospective Observational Cohort Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
his is a single-center, prospective observational study in children and adolescents with central nervous system tumors who need whole-brain and whole-spine radiation therapy (craniospinal irradiation, CSI). The study uses proton therapy with a special vertebral body-sparing (VBS) technique to protect the front and center of the vertebrae, which helps preserve bone marrow function and growth. The main goals are to find safe dose limits for the vertebrae and check how often severe side effects occur. The study will also look at bone marrow preservation, spinal deformity, tumor control, survival, chemotherapy completion, neurocognitive function, quality of life, and growth and development for up to 5 years after treatment.
Conditions
Conditions (5)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Atypical Teratoid/Rhabdoid Tumor (AT/RT) | Atypical Teratoid/Rhabdoid Tumor | ONTOLOGY_EXACT | 0.85 |
| Ependymoma | Ependymoma | ONTOLOGY_EXACT | 0.90 |
| Germinoma | Germinoma | ONTOLOGY_EXACT | 0.90 |
| Medulloblastoma | Medulloblastoma | CURATED_BROADER | 0.80 |
| Pediatric Central Nervous System Tumors | Childhood Central Nervous System Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Vertebral Body-Sparing Craniospinal Proton Irradiation | Radiation | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- Low-Dose Cohort
- description
- Patients in the low-dose cohort receive vertebral body-sparing craniospinal irradiation (VBS-CSI) using pencil-beam scanning proton therapy at a prescription dose of 23.4 Gy(RBE) in 13 fractions or 24 Gy(RBE) in 15 fractions.
- interventionNames
- Radiation: Vertebral Body-Sparing Craniospinal Proton Irradiation
- label
- High-Dose Cohort
- description
- Patients in the high-dose cohort receive vertebral body-sparing craniospinal irradiation (VBS-CSI) using pencil-beam scanning proton therapy at a prescription dose of 36 Gy(RBE) in 20 fractions.
- interventionNames
- Radiation: Vertebral Body-Sparing Craniospinal Proton Irradiation
Primary outcomes (1)
- measure
- Incidence of ≥ Grade 3 acute adverse events
- timeFrame
- Up to 3 months after completion of radiotherapy
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 4 Years
- Maximum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * The patient's legal guardian voluntarily signs the written informed consent form. * Age at diagnosis \> 3 years and ≤ 18 years. * Histopathologically confirmed diagnosis of a central nervous system (CNS) tumor. * Indication for craniospinal irradiation (CSI) confirmed by multidisciplinary team (MDT) discussion. * Karnofsky Performance Score (KPS) ≥ 80. * For postoperative patients, complete healing of the surgical incision with no evidence of wound infection or other complications. * For women of childbearing potential, effective contraception must be used for at least one month prior to screening, and they must commit to continued contraception throughout the study period and for the required time after study completion. Exclusion Criteria: * Previous receipt of any form of spinal radiotherapy. * Previous major spinal surgery for any reason. * Presence of clinically significant and confirmed spinal deformity at enrollment (e.g., Cobb angle \> 10° measured by MRI or X-ray). * Presence of medical contraindications to proton radiotherapy. * Presence of any severe, uncontrolled systemic disease (e.g., active infection, severe cardiac, hepatic, renal, or respiratory insufficiency) that, in the investigator's judgment, makes the subject unsuitable for treatment under this protocol. * Female patients who are pregnant or breastfeeding. * Presence of any severe cognitive or psychiatric disorder that prevents understanding of or cooperation with study assessments.
References
Publications (0)
Data not yet available