Clinical trial · Observational
Anemia on Sublingual Microcirculation in GDFT
Effects of Anemia on Sublingual Microcirculation in Patients Undergoing Goal-Directed Fluid Therapy: A Prospective Observational Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The goal of this observational study is to learn about the effects of anemia on sublingual microcirculation in patients undergoing goal-directed fluid therapy (GDFT) during surgery. The main question it aims to answer is: Does anemia, under the condition of goal-directed fluid therapy, lead to significant changes in sublingual microcirculatory parameters (such as microvascular density and perfusion)? Participants will include 54 patients scheduled for elective open radical gastrectomy (27 anemic vs. 27 non-anemic). Sublingual microcirculation will be assessed using a side-stream dark field imaging device at four time points: before anesthesia induction (T0), after induction (T1), after specimen removal (T2), and after anastomosis completion (T3). All patients will receive intraoperative GDFT guided by pulse pressure variation (PPV) and cardiac output (CO) via the Vigileo-FloTrac system.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Anemia in Patients Undergoing Gastric Cancer Surgery Under Goal-directed Fluid Therapy | — | UNRESOLVED | — |
| Macro-microcirculation Uncoupling | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| No intervention | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- Anemic Group
- description
- Patients with preoperative hemoglobin (Hb) ≤ 10 g/dL scheduled for elective open radical gastrectomy. All patients receive standardized goal-directed fluid therapy (GDFT) and undergo sublingual microcirculation assessment at four time points: before anesthesia induction (T0), after induction (T1), after specimen removal (T2), and after anastomosis completion (T3).
- interventionNames
- Other: No intervention
- label
- Non-anemic Group
- description
- Patients with preoperative hemoglobin (Hb) \> 10 g/dL scheduled for elective open radical gastrectomy. All patients receive standardized goal-directed fluid therapy (GDFT) and undergo sublingual microcirculation assessment at four time points: before anesthesia induction (T0), after induction (T1), after specimen removal (T2), and after anastomosis completion (T3).
- interventionNames
- Other: No intervention
Primary outcomes (4)
- measure
- Total Vessel Density (TVD)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Scheduled for elective open radical gastrectomy * Age ≥ 18 years * ASA physical status I-III * Undergoing general anesthesia with endotracheal intubation Exclusion Criteria: * Untreated ischemic heart disease or severe cardiovascular disease * Acute or chronic respiratory failure, severe asthma, pulmonary bullae, pneumothorax, emphysema, bronchopleural fistula * Oral or tongue disorders * Scheduled for laparoscopic surgery * Inability to position or observe the patient's head during surgery * Refusal to participate after entering the operating room * Intraoperative life-threatening events * Hemodynamic instability during surgery
References
Publications (0)
Data not yet available