Clinical trial · Observational
100-Year Human Aging Study
100-Year Human Aging Study: Prospective Longitudinal Validation of Multi-System Health Measurements Against Mortality and Aging Outcomes
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 9, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260909-000002
Summary
Brief summary (as posted)
The 100-Year Human Aging Study is a prospective, pragmatic, observational trial enrolling participants across fixed clinical sites, mobile clinical sites, and an online participation pathway (current and future) to undergo comprehensive multi-system health screening and longitudinal follow-up until death. Participants are followed to determine whether measurements taken at enrollment and repeated across the lifespan - individually and in combination - predict all-cause mortality, cause-specific mortality, incident serious disease, and functional disability. The study is designed to generate the surrogate endpoint validation data that longevity medicine currently lacks.
Conditions
Conditions (15)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Activities of Daily Living | — | UNRESOLVED | — |
| Aging | — | UNRESOLVED | — |
| Aging Well | — | UNRESOLVED | — |
| All-Cause Mortality | — | UNRESOLVED | — |
| Cardiovascular Diseases | — | UNRESOLVED | — |
| Cognitive Dysfunction | — | UNRESOLVED | — |
| Dementia | — | UNRESOLVED | — |
| Disability Physical | — | UNRESOLVED | — |
| Frailty | — | UNRESOLVED | — |
| Health-Related Quality of Life |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Comprehensive Multi-System Clinical Screening | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (2)
- measure
- All-Cause Mortality
- timeFrame
- From enrollment until death, assessed periodically, up to 100 years
- description
- Vital status ascertained through longitudinal follow-up contact, mortality record linkage, and health data network linkage using probabilistic matching on name, date of birth, and address history.
- measure
- Cause-Specific Mortality
- timeFrame
- From enrollment until death, assessed periodically, up to 100 years
- description
- Cause of death ascertained via death certificate and mortality record linkage.
Secondary outcomes (7)
- measure
- Cause-Specific Mortality Prediction Accuracy
- timeFrame
- From enrollment until death, assessed periodically, up to 100 years
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Age 18 years or older * Willing and able to provide written informed consent, or enrollment with consent of a legally authorized representative * Willing to participate in longitudinal follow-up Exclusion Criteria: * Age under 18 years
References
Publications (0)
Data not yet available