Clinical trial · Interventional
Measuring Brain Changes Following Cognitive Intervention in Pediatric Patients With Brain Tumors
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The goal of this study is to learn if an online computerized training program improves processing speed, attention, and working memory in children with a primary brain tumor during and after active cancer treatment. The main questions it aims to answer are: 1. Is the cognitive intervention feasible to administer to children with brain tumors during and after cancer treatment?, 2. Is the cognitive intervention acceptable to children and caregivers?, and 3. Does the cognitive intervention improve neuropsychological functioning? There is no comparison group for this study. Participants will: 1. Complete an online computerized cognitive training program for approximately 15 minutes per day, 5 days a week, for 8 weeks; 2. Have weekly check-ins with the cognitive coach, 3. Complete a survey at the end of the cognitive training program, and 4. Complete pre- and post- neuropsychological testing.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Brain Tumor, Pediatric | Childhood Brain Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Online computerized cognitive training intervention focused on processing speed. | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Cognitive Intervention
- description
- Computerized cognitive training program focused on processing speed.
- interventionNames
- Behavioral: Online computerized cognitive training intervention focused on processing speed.
Primary outcomes (5)
- measure
- Feasibility - Enrollment
- timeFrame
- Up to 5 years after diagnosis.
- description
- Study enrollment rate.
- measure
- Feasibility - Participant Retention
- timeFrame
- 8 weeks
- description
- Number of participants who complete the computerized brain training program.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 5 Years
- Maximum age
- 25 Years
Show eligibility criteria text
Inclusion Criteria: 1. Diagnosis of a primary brain tumor, 2. Children and young adults 5 to 25 years of age at the time of enrollment, 3. Within five years of initial brain tumor diagnosis, 4. Receiving care through the Johns Hopkins neuro-oncology program. Exclusion Criteria: 1. Significant visual, hearing, motor, or cognitive impairment that precludes participation in computerized cognitive training program; 2. Acute medical status (e.g., significant risk for mortality within 3-months of diagnosis).
References
Publications (4)
- BACKGROUNDMeneses K, Benz R, Bail JR, Vo JB, Triebel K, Fazeli P, Frank J, Vance DE. Speed of processing training in middle-aged and older breast cancer survivors (SOAR): results of a randomized controlled pilot. Breast Cancer Res Treat. 2018 Feb;168(1):259-267. doi: 10.1007/s10549-017-4564-2. Epub 2017 Nov 11. PMID 29128897
- BACKGROUNDMaeir T, Makranz C, Peretz T, Odem E, Tsabari S, Nahum M, Gilboa Y. Cognitive Retraining and Functional Treatment (CRAFT) for adults with cancer related cognitive impairment: a preliminary efficacy study. Support Care Cancer. 2023 Feb 7;31(3):152. doi: 10.1007/s00520-023-07611-y. PMID 36746805
- BACKGROUNDAreklett EW, Hagen BI, Stubberud J, Fagereng E, Andersson S, Lindemann K. Digital goal management training for cognitive impairment in cervical cancer survivors-a randomized comparison study. J Cancer Surviv. 2026 Jun;20(3):978-989. doi: 10.1007/s11764-024-01701-4. Epub 2024 Nov 22. PMID 39576570
- BACKGROUNDJacola LM, Peterson RK, Oswald-McCloskey KA, Sekely A, Mabbott DJ, Edelstein K. Neuropsychological function in childhood cancer patients and adult survivors of childhood cancer. J Clin Exp Neuropsychol. 2025 Oct;47(8):788-805. doi: 10.1080/13803395.2025.2521018. Epub 2025 Jul 9. PMID 40635330