Clinical trial · Interventional
Bleeding Control Methods in Open Myomectomy
Effects of Different Intraoperative Bleeding Control Methods on Haematological Outcomes and the Amount of Bleeding in Open Myomectomy: A Prospective Randomized Controlled Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Excessive intraoperative bleeding remains a major challenge during open myomectomy and may lead to postoperative anemia and increased morbidity. Numerous methods have been proposed to minimize hemorrhage; however, evidence regarding their effectiveness in open surgery remains limited. This prospective randomized controlled trial aims to evaluate the effects of tourniquet application, uterine artery bulldog clamping, and no-compression techniques on intraoperative blood loss and postoperative hematological parameters in patients undergoing open myomectomy. A total of 120 patients undergoing open myomectomy will be randomly assigned to three groups: tourniquet group (n = 40), uterine artery bulldog clamp group (n = 40), and no-compression group (n = 40). The primary outcome is intraoperative blood loss. Secondary outcomes include hemoglobin (Hb) and hematocrit (Hct) levels at 24 and 48 hours postoperatively. Myoma volume will be calculated using the spherical formula based on the maximum myoma diameter. Statistical analyses will be performed using one-way analysis of variance (ANOVA) or the Kruskal-Wallis test, as appropriate.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Uterine Leiomyomas | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Tourniquet application | Procedure | — | UNRESOLVED |
| Uterine artery bulldog clamp | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- type
- EXPERIMENTAL
- label
- Tourniquet group
- description
- Participants undergoing open myomectomy in whom an elastic surgical tourniquet was applied at the level of the lower uterine segment/cervix to temporarily reduce uterine blood flow during surgery.
- interventionNames
- Procedure: Tourniquet application
- type
- EXPERIMENTAL
- label
- Bulldog clamp group
- description
- Participants undergoing open myomectomy in whom bilateral uterine arteries were dissected and temporarily occluded using bulldog clamps during surgery to control intraoperative bleeding.
- interventionNames
- Procedure: Uterine artery bulldog clamp
- type
- NO_INTERVENTION
- label
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
- Maximum age
- 50 Years
Show eligibility criteria text
Inclusion Criteria: * Women aged between 18 and 50 years * Diagnosis of symptomatic uterine leiomyoma * Planned abdominal (open) myomectomy * No additional surgical procedure performed during the operation * Availability of complete preoperative and postoperative laboratory data Exclusion Criteria: * Pregnancy or suspected pregnancy * Presence of more than 7 myomas * Suspicion or diagnosis of uterine malignancy * History of coagulopathy or use of anticoagulant/antiplatelet therapy * Preoperative blood transfusion * Concomitant major surgical procedures (e.g., hysterectomy or adnexal surgery) * History of previous myomectomy * Incomplete laboratory or clinical data
References
Publications (1)
- DERIVEDKara U, Karaaslan O. Uterine artery bulldog clamping versus tourniquet for reducing blood loss in open myomectomy: a randomized controlled trial. Sci Rep. 2026 Aug 4;16(1):27388. doi: 10.1038/s41598-026-64820-1. PMID 42680787