Clinical trial · Interventional
Lungs on Fire: Wildfire Smoke, Incident Diseases, Susceptible Populations, and Community Values in Canada
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Wildfire smoke (WFS) is the leading climate-related risk in Canada and the main source of harmful air pollution. While short-term breathing problems caused by smoke are well known, there is limited knowledge on how repeated exposure contributes to long-term lung disease. This study is a controlled human exposure to varying concentrations of WFS in a safe setting. By comparing the effects of different concentrations, this research will improve understanding of health impacts, identify who may be most vulnerable to exposures, and explore biological changes that could lead to chronic illness.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Asthma | — | UNRESOLVED | — |
| Chronic Obstructive Pulmonary Disease (COPD) | — | UNRESOLVED | — |
| Lung Cancer | Malignant Lung Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Filtered air exposure | Other | — | UNRESOLVED |
| Woodsmoke (Lodgepole Pine) exposure | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- type
- EXPERIMENTAL
- label
- Arm A) Three repeated exposures to a low air pollution concentration
- description
- Three consecutive days with a 2-hour woodsmoke exposure at 35 µg/m3 of PM2.5 each day.
- interventionNames
- Other: Woodsmoke (Lodgepole Pine) exposure
- type
- EXPERIMENTAL
- label
- Arm B) Three repeated exposures to a moderate air pollution concentration
- description
- Three consecutive days with a 2-hour woodsmoke exposure at 105 µg/m3 of PM2.5 each day.
- interventionNames
- Other: Woodsmoke (Lodgepole Pine) exposure
- type
- EXPERIMENTAL
- label
- Arm C) Single exposure to a higher air pollution concentration
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 19 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * Healthy Adults between the ages of 19 to 80 (12 of each biological sex assigned at birth). Exclusion Criteria: 1. Current smoker (within six months before screening; potential to confound exposure effects). 2. History or current diagnosis of any respiratory conditions (including, but not limited to asthma or chronic obstructive pulmonary disease (COPD), asthma/COPD overlap) or other medical conditions that the study physician determines may impact participant safety. 3. Any comorbidities or other concerns identified by the study physician which may impact study participation. 4. For participants of child-bearing potential: Current pregnancy, or plans to become pregnant during study enrolment.
References
Publications (0)
Data not yet available