Clinical trial · Observational
Muscle Aging Phenotypes in Childhood Cancer Survivors
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 17, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260917-000001
Summary
Brief summary (as posted)
Childhood cancer survivors experience premature declines in muscle mass, strength, and physical function that contribute to morbidity and early mortality. The biological mechanisms driving these impairments are heterogeneous and poorly understood. This observational study aims to characterize distinct muscle health endotypes in adult survivors of childhood cancer using advanced imaging, neuromuscular testing, and functional assessment. Survivors with reduced muscle health and community controls will undergo multimodal magnetic resonance imaging and spectroscopy, nerve conduction studies, surface electromyography, body composition assessment, and physical performance testing during a single study visit integrated into an ongoing cohort evaluation. Identifying mechanistic endotypes of impaired muscle health will support development of targeted interventions to preserve function and improve long-term outcomes in childhood cancer survivors. Primary Objective: \- Characterize reduced muscle health endotypes in childhood cancer survivors. Secondary Objective: \- Identify specific treatment and lifestyle related risk factors for each reduced muscle health endotype. Exploratory Objective: \- Host germline genetics will be associated with specific muscle endotypes.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Low Muscle Mass | — | UNRESOLVED | — |
| Muscle Weakness | — | UNRESOLVED | — |
| Sarcopenia | — | UNRESOLVED | — |
Interventions
Interventions (4)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Comprehensive Muscle Phenotyping | Other | — | UNRESOLVED |
| Integrated Neuromuscular and Imaging Evaluation | Other | — | UNRESOLVED |
| Multimodal Muscle Imaging and Functional Assessment | Other | — | UNRESOLVED |
| Multimodal Muscle Imaging and Neuromuscular Assessment | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (4)
- label
- Community Controls
- description
- Adults with no history of cancer recruited from the community or non-first-degree relatives of St. Jude patients.
- interventionNames
- Other: Multimodal Muscle Imaging and Functional Assessment
- label
- Survivors With Low Lean Mass or Weakness and Peripheral Neurotoxin Exposure
- description
- Adult childhood cancer survivors with low lean mass and/or muscle weakness and documented exposure to peripheral neurotoxic therapies.
- interventionNames
- Other: Multimodal Muscle Imaging and Neuromuscular Assessment
- label
- Survivors With Low Lean Mass or Weakness Without Peripheral Neurotoxin Exposure
- description
- Adult childhood cancer survivors with low lean mass and/or muscle weakness and no history of exposure to peripheral neurotoxic therapies.
- interventionNames
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Age 18 years old or older at time of consent and enrolled in SJLIFE. * Participant (100 per group for a total of 400) is/has: * Group 1: No cancer history * Group 2: Age and sex specific relative lean mass z-score of less than -0.5 OR age and sex specific hand grip or isokinetic (60 degrees/sec) quadriceps strength z-score of \<-0.5 AND exposure to a peripheral neurotoxin. * Group 3: Age and sex specific relative lean mass z-score of less than -0.5 OR age and sex specific hand grip or isokinetic (60 degrees/sec) quadriceps strength z-score of \<-0.5 AND NOT exposed to a peripheral neurotoxin. * Group 4: Age and sex specific relative lean mass z-score of less than -0.5 AND age and sex specific hand grip strength or isokinetic (60 degrees/sec) quadriceps strength z-score of \<-0.5 REGARDLESS of exposure status. * Participant or legal guardian is able and willing to give informed consent. Exclusion Criteria: * Presence of implanted medical devices or metal that would interfere with MRI or MRS. * Female Participant is pregnant. * Body weight exceeding 300 pounds, due to MRI restrictions. * Inability to lie flat on his/her back for 90 minutes or longer for MRI. * Inability or unwillingness of research participant or legal guardian/representative to give written informed consent. * Presence of known radiation-induced nerve injury. * Prescence of pre-existing neurologic (non-cancer related) or who develop chronic neurologic disorders (i.e. Charcot Marie Tooth Disease, Downs, congenital brain injury). * Participation on a lifestyle or medication clinical trial within the past 1 year.
References
Publications (0)
Data not yet available