Clinical trial · Observational
Association Between Chronic Psychological Stress and Disease Course Outcomes in Pancreatic Cancer
A Prospective Cohort Study on the Association Between Chronic Psychological Stress and Disease Course Outcomes in Pancreatic Cancer: A Comprehensive Analysis Based on Multidimensional Dynamic Psychological Assessment (MIND-PANC)
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This is a prospective, observational cohort study (MIND-PANC) to explore the associations of chronic psychological stress with disease progression, treatment outcomes, and prognosis of pancreatic cancer. Researchers will ask participants to fill out simple questionnaires about their mood, worries, and sleep at the start of the study and at regular follow-up visits. The study will also collect a small blood sample (leftover from routine care) to measure stress-related markers. Investigators hypothesize that pancreatic cancer patients who have higher levels of ongoing psychological stress (such as anxiety, depression, or poor sleep) tend to have shorter survival times, a higher chance of recurrence, and a poorer response to treatment, compared to patients with lower stress levels.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Pancreatic Cancer, Adult | Malignant Pancreatic Neoplasm | CURATED_EXACT | 0.85 |
| Pancreatic Cancer Resectable | — | UNRESOLVED | — |
| Pancreatic Tumor, Benign | Benign Pancreatic Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (2)
- label
- High Stress Cohort
- description
- Pancreatic cancer patients who receive radical resection and exhibit high psychological stress (e.g., defined by a specific cut-off score on the evaluation scale).
- label
- Low Stress Cohort
- description
- Pancreatic cancer patients who receive radical resection and exhibit low or normal psychological stress
Primary outcomes (1)
- measure
- overall survival
- timeFrame
- 3 years
- description
- Overall survival (OS) is defined as the duration from the beginning of therapy until death due to any cause.
Secondary outcomes (4)
- measure
- progression-free-survival
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Age ≥ 18 years. * Histologically or cytologically confirmed diagnosis of pancreatic cancer, or other pancreatic diseases. * Conscious, with basic reading/writing or communication skills, able to understand and complete the questionnaire assessments (either independently, with assistance from research staff, or with help from a family member). * Voluntarily agree to participate in this study and sign a written informed consent form. Exclusion Criteria: * Presence of severe cognitive impairment (e.g., dementia, disturbance of consciousness) or a definite history of psychiatric disorders, judged by the investigator as unable to comply with the study assessments, and without a family member who can help complete the questionnaire assessments. * Presence of other severe, uncontrolled systemic diseases (e.g., severe heart, lung, or kidney failure), with an estimated life expectancy \< 3 months as judged by the investigator. * Inability to understand Chinese or presence of severe visual/hearing impairment that affects completion of the questionnaire assessments, and without a family member who can help complete the questionnaire assessments.
References
Publications (8)
- RESULTPeng F, Lu J, Su K, Liu X, Luo H, He B, Wang C, Zhang X, An F, Lv D, Luo Y, Su Q, Jiang T, Deng Z, He B, Xu L, Guo T, Xiang J, Gu C, Wang L, Xu G, Xu Y, Li M, Kelley KW, Cui B, Liu Q. Oncogenic fatty acid oxidation senses circadian disruption in sleep-deficiency-enhanced tumorigenesis. Cell Metab. 2024 Jul 2;36(7):1598-1618.e11. doi: 10.1016/j.cmet.2024.04.018. Epub 2024 May 20. PMID 38772364
- RESULTPariollaud M, Ibrahim LH, Irizarry E, Mello RM, Chan AB, Altman BJ, Shaw RJ, Bollong MJ, Wiseman RL, Lamia KA. Circadian disruption enhances HSF1 signaling and tumorigenesis in Kras-driven lung cancer. Sci Adv. 2022 Sep 30;8(39):eabo1123. doi: 10.1126/sciadv.abo1123. Epub 2022 Sep 28. PMID 36170373
- RESULTPeng Z, Song J, Zhu W, Bao H, Hu Y, Shi Y, Cheng X, Jiang M, Fang F, Chen J, Shu X. Impact of sleep deprivation on colon cancer: Unraveling the KynA-P4HA2-HIF-1alpha axis in tumor lipid metabolism and metastasis. Mol Metab. 2025 Mar;93:102109. doi: 10.1016/j.molmet.2025.102109. Epub 2025 Feb 6. PMID 39920992
- RESULTLiu JL, Xu X, Rixiati Y, Wang CY, Ni HL, Chen WS, Gong HM, Zhang ZL, Li S, Shen T, Li JM. Dysfunctional circadian clock accelerates cancer metastasis by intestinal microbiota triggering accumulation of myeloid-derived suppressor cells. Cell Metab. 2024 Jun 4;36(6):1320-1334.e9. doi: 10.1016/j.cmet.2024.04.019. PMID 38838643
- RESULTLi Y, Yu H, Li ZM, Yin KW, Jin SY, Chen CC, Tan MS, Zhang CJ, Liu XH, Li WP, Yang JM, Zhou AJ, Zhang X, Ni ED, Wang ML, Mo H, Qin C, Hu J, Li SJ, Gao TM, Li JM. Colorectal cancer cells hijack a brain-gut polysynaptic circuit from the lateral septum to enteric neurons to sustain tumor growth. Nat Cancer. 2025 Nov;6(11):1800-1820. doi: 10.1038/s43018-025-01033-x. Epub 2025 Aug 21. PMID 40841473
- RESULTZhou R, Li K, Hu X, Fan S, Gao Y, Xue X, Bu Y, Zhang H, Wang Y, Wei C, Zhang S, Xie Z, Liu C, Chen P, Yin Z, Ren D. Sleep Deprivation Activates a Conserved Lactate-H3K18la-RORalpha Axis Driving Neutrophilic Inflammation Across Species. Adv Sci (Weinh). 2025 Oct;12(38):e04028. doi: 10.1002/advs.202504028. Epub 2025 Jul 21.