Clinical trial · Observational
Cardiopulmonary Exercise Testing in Lung Cancer Patients Before and During Oncological Treatment
Assessment of Respiratory Parameters and Physical Performance in Patients With Lung Cancer Qualified for Oncological Treatment Before and During Therapy, With Special Consideration of Cardiovascular Risk: A Cardiopulmonary Exercise Testing Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Patients with lung cancer often have reduced physical fitness and coexisting health problems, which may limit their ability to tolerate oncological treatment. Standard resting lung and heart tests do not always reflect real-life physical capacity during everyday activities or physical effort. This observational study aims to assess cardiorespiratory fitness in patients with lung cancer before and during standard oncological treatment using cardiopulmonary exercise testing (CPET). CPET is a safe, supervised exercise test that provides objective information on how the heart, lungs, and muscles respond to physical effort. Participants with WHO/ECOG performance status 0-2 will undergo CPET before treatment initiation and again after the early phase of therapy or surgery. The results may help identify patients with reduced physiological reserve and support individualized monitoring during routine clinical care.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Non-Small Cell Carcinoma of Lung | Lung Non-Small Cell Carcinoma | ALIAS | 0.90 |
| Small Cell Carcinoma of Lung | Lung Small Cell Carcinoma | ALIAS | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Cardiopulmonary Exercise Testing (CPET) | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Lung cancer cohort
- description
- Adult patients (≥18 years) with histologically confirmed lung cancer (any stage) and WHO/ECOG performance status 0-2, qualified for standard oncological management. Participants undergo cardiopulmonary exercise testing (CPET) at baseline (before treatment) and after the early phase of standard oncological therapy or surgery.
- interventionNames
- Diagnostic Test: Cardiopulmonary Exercise Testing (CPET)
Primary outcomes (1)
- measure
- Change in peak oxygen uptake (VO2peak) measured by cardiopulmonary exercise testing
- timeFrame
- Baseline and 6-8 weeks after treatment initiation or approximately 6 weeks after surgery
- description
- Within-participant change in peak oxygen uptake (VO2peak, mL/kg/min) assessed during symptom-limited cardiopulmonary exercise testing at baseline (before treatment initiation) and at follow-up after the early phase of standard oncological therapy or surgery.
Secondary outcomes (3)
- measure
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Age ≥ 18 years * Histologically confirmed lung cancer (any stage) * Qualified for standard oncological management (surgery and/or systemic therapy) * WHO/ECOG performance status 0-2 * Ability to perform cardiopulmonary exercise testing (CPET) * Written informed consent Exclusion Criteria: * Unstable ischemic heart disease * Symptomatic cardiac arrhythmias * Myocarditis or pericarditis * Decompensated heart failure * Active deep vein thrombosis * Suspected aortic dissection or severe aortic stenosis * Poorly controlled asthma * Resting oxygen saturation ≤ 85% on room air * Clinically relevant treatment-related adverse events above mild intensity (as applicable) * Any medical condition that, in the investigator's opinion, precludes safe participation in CPET * Withdrawal of informed consent
References
Publications (0)
Data not yet available