Concomitant Trans-Perineal Prostate Biopsy and Ablation (Bioblation) for Prostate Cancer

This prospective study aims to validate the clinical outcomes of performing a concomitant trans-perineal prostate biopsy and laser ablation (termed "Bioblation") during a single session. The intervention is designed for symptomatic patients presenting with lower urinary tract symptoms (LUTS) who are highly suspected to have low to favorable intermediate-risk prostate cancer. By combining diagnosis and targeted treatment under local anesthesia, this approach seeks to facilitate early relief of severe symptoms and a rapid return to daily activities. Ultimately, the study evaluates whether this combined procedure decreases the patient's exposure to multiple, temporally separated interventions without compromising oncological safety or efficacy.

Sex

Male

Minimum age

18 Months

Inclusion Criteria:

* Patients with severe Lower Urinary Tract Symptoms (LUTS) meeting the following parameters:

  1. IPSS score \> 20
  2. Uroflowmetry flow rate \< 10 ml/sec
  3. Post-void residual \> 150 cc
* Patients most probably having low to favorable intermediate-risk prostate cancer, defined as:

  1. PSA level between 4 and 20 ng/ml
  2. MP-MRI showing 3 or fewer focal lesions
  3. MP-MRI focal lesions measuring \< 1.5 cm
* International or visiting patients requiring early return to their home country due to professional or personal commitments, provided they can undergo short-term management and follow-up coordination

Exclusion Criteria:

* Patient PSA level \> 20 ng/ml
* More than 3 focal lesions on MP-MRI
* Metastatic prostate cancer
* History of lower urinary tract surgery (e.g., TURP, Laser, urinary diversions, artificial urinary sphincter)
* History of pelvic radiation therapy or radical pelvic surgery

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