One-stop Diagnosis and Treatment for Suspected Lung Cancer: Combined RBS, nClE, OBCT and Ablation

Inclusion Criteria:

* Age ≥18 years, male or female.
* High-risk pulmonary nodule/tumor maximum diameter ≤3 cm.
* Lesion judged suitable for bronchial navigation-guided diagnosis and treatment.
* Ineligible for surgery or refuses surgery/radiotherapy; agrees to primary ablation therapy; provides written informed consent.

Exclusion Criteria:

* Diffuse bilateral lung lesions unresponsive to ablation.
* Contraindication to bronchoscopy or inability to tolerate/cooperate with bronchoscopy.
* Severe bleeding tendency or irreversible coagulopathy (PT \>18 s, PTA \<40%).Platelet count \<70×10⁹/L; anticoagulant/antiplatelet therapy discontinued \<1 week before ablation (except prophylactic low-molecular-weight heparin).
* Severe pulmonary impairment (maximal voluntary ventilation \<40%).
* Other metastatic tumors with widespread metastasis; life expectancy \<3 months.
* Poor general condition: widespread metastasis, severe infection, high fever, infectious/radiation inflammation around the lesion, obvious cachexia, severe organ dysfunction, severe anemia, uncorrectable metabolic/nutritional disorders.
* Eastern Cooperative Oncology Group (ECOG) performance status \>2.
* Target lesion received radiotherapy within the past 6 months.
* Active hepatitis B, active hepatitis C, known HIV-1/2 antibody positivity, or other active infections judged by the investigator to interfere with treatment.
* History of epilepsy, psychosis, or cognitive impairment.
* Pregnant/lactating females; males or females planning conception during the trial.
* Other conditions deemed inappropriate by the investigator.