Clinical Study on the Safety and Immunogenicity of Specific Cancer Vaccines in Preventing Recurrence of Glioblastoma

Inclusion Criteria:

* The patient must voluntarily sign the informed consent form and demonstrate good compliance during follow-up.
* Age ≥18 years, both male and female participants are eligible.
* Supratentorial IDH-wildtype glioblastoma located in the frontal, temporal, or occipital lobe with EGFR gene mutation; complete tumor resection confirmed by imaging within 10 days after initial surgery, followed by standard radiotherapy and/or chemotherapy; no tumor recurrence observed on MRI at 4 months postoperatively.
* Karnofsky Performance Status (KPS) score ≥60 before treatment.
* Normal immune function, bone marrow reserve, and normal liver and kidney function: absolute neutrophil count ≥1,500/mm³; hemoglobin ≥10 g/dL; platelet count ≥100,000/mm³; total bilirubin ≤1.5 × ULN; ALT/AST ≤2.5 × ULN; serum creatinine ≤1.5 × ULN; normal cardiac function.
* Women of childbearing age (15-49 years) must have a negative pregnancy test within 7 days prior to the start of treatment; male and female patients of reproductive potential must agree to use effective contraception during the study period and for 6 months after treatment.

Exclusion Criteria:

* Unwilling or unable to undergo treatment and follow-up assessments;
* History of brachial neuritis or Guillain-Barré syndrome.
* History of organ transplantation or currently awaiting organ transplantation;
* Uncontrolled infectious diseases or other serious conditions, such as HIV, or seropositivity for hepatitis B or hepatitis C.
* Any unstable systemic disease, including but not limited to: active infections, uncontrolled hypertension, unstable angina, newly onset angina within the past 3 months, congestive heart failure, myocardial infarction within 12 months prior to enrollment, severe arrhythmias requiring medical treatment, liver or renal failure.
* Patients with systemic autoimmune diseases or immunodeficiency disorders.
* Patients with a history of severe allergies.
* Patients with chronic diseases requiring long-term treatment with immunosuppressants or corticosteroids.
* Pregnant or breastfeeding women.