Clinical trial · Observational
C-3002: Enhancing Cervical Cancer Screening Access and Follow-up Care at 'CASCADE' Clinical Sites in the United States
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of the CASCADE-3002 project is to improve access to cervical cancer screening among women with Human Immunodeficiency Virus (HIV) receiving care at U.S.-based CASCADE clinical sites. This study will assess the cervical cancer screening cascade and identify multilevel factors that impede access to screening among women with HIV attending Infectious Disease clinics in Georgia and Maryland. In parallel, the study will explore and develop implementation strategies for human papillomavirus (HPV) self-collection to increase screening uptake, adherence, and appropriate clinical follow-up in this population at elevated risk for cervical cancer. Cervical cancer remains a preventable malignancy; however, women with HIV are at substantially increased risk and experience higher rates of cervical cancer compared with women without HIV. The World Health Organization has called for the global elimination of cervical cancer as a public health problem, defined as fewer than 4 incident cases per 100,000 women annually, with targets for vaccination, screening, and treatment coverage. Although the United States has the tools to approach near-elimination, disparities in healthcare access and screening persist, particularly among women with HIV.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cervical Cancer | Malignant Cervical Neoplasm | CURATED_EXACT | 0.92 |
| Cervical Precancer | — | UNRESOLVED | — |
| Human Immunodeficiency Virus (HIV) | — | UNRESOLVED | — |
| Human Papillomavirus (HPV) | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Focus groups | Behavioral | — | UNRESOLVED |
| Qualitative interviews | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- Women with Human Immunodeficiency Virus (HIV)
- description
- Women with Human Immunodeficiency Virus (HIV) are eligible for cervical cancer screening.
- interventionNames
- Behavioral: Qualitative interviews
- label
- Healthcare providers
- description
- Healthcare providers (e.g. physicians, nurse practitioners, physician's assistants, nurses, nursing assistants, medical assistants, pharmacists), laboratory members, and IT Specialist/Medical Records Experts providing care to WWH.
- interventionNames
- Behavioral: Focus groups
Primary outcomes (1)
- measure
- Determination of the Cervical Cancer Screening Cascade
- timeFrame
- Baseline
- description
- The cervical cancer screening cascade will be documented among screen-eligible patients in Infectious Disease HIV care clinics associated with US-based 'CASCADE' Clinical Sites (CS4 Georgia (GA) and CS8 Maryland (MD)) by constructing a cohort via retrospective chart review.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 25 Years
Show eligibility criteria text
Aim 1a- Retrospective Chart Review Inclusion Criteria: Health records of WWH who are ages 25 and over, clients of the participating clinics, and eligible for cervical cancer screening per national US guidelines, during the time period of September 1, 2022 to August 31, 2025. Aim 1b Inclusion Criteria * women with Human Immunodeficiency Virus (HIV) receive care * ages between 25- 49 * eligible for cervical cancer screening per national US guidelines Aim 1b Exclusion Criteria • Women without an intact cervix. Aim 2 Inclusion Criteria: * Clinical team members who work and provide care to women living with HIV at three clinical locations: the Center for Infectious Diseases (CID) at the University of Maryland School of Medicine in Baltimore, MD; Ponce de Leon Clinic at Emory University in Atlanta, GA; and Albany Area Primary Health Care in Albany, GA. * Clinical team members will include: providers (Physicians, Nurse practitioners, Physician's Assistants, Nurses, Nursing Assistants, Medical Assistants, Pharmacists), laboratory members, or other staff involved in clinic operations. Aim 2 Exclusion Criteria • Individuals who do not work for the Center for Infectious Diseases (CID) at the University of Maryland School of Medicine in Baltimore, MD or the Ponce de Leon Clinic at Emory University in Atlanta, GA.
References
Publications (0)
Data not yet available