Clinical trial · Interventional
Implementing Low-dose ct Lung Cancer Screening in France.
NCT07513818CI-TRIAL-00113767IMPULSIONrecruitingN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The main objective is to estimate the detection rate of lung cancer in the population screened by low-dose chest CT scans.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Lung Cancer | Malignant Lung Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Low-dose computed tomography of the chest | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- Lung cancer detection rate in the population screened using low-dose chest CT
- timeFrame
- 42 months
- description
- Number of individuals with detected cancer divided by the number of individuals included in the study, i.e., an intention-to-screen analysis.
Secondary outcomes (23)
- measure
- Evaluation of screening performance
- timeFrame
- 42 months
- description
- * True positives: positive screening result and confirmation of malignancy. * True negatives: negative screening result (absence of nodules, or nodules not meeting the criteria for a positive or indeterminate screening, see algorithms), including during retrospective review in cases where cancer is diagnosed within the following year. * False positives: positive screening result but malignancy not confirmed after appropriate investigation(s). * False negatives: CT screening considered negative, but cancer is diagnosed within the coming year and the CT scan is retrospectively interpreted as positive or indeterminate.
- measure
- Exploration and comparison of several methods for identifying and inviting the target population
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 50 Years
- Maximum age
- 74 Years
Show eligibility criteria text
Inclusion Criteria: * Adults aged 50-74 years * Active or former smoker having quit less than 15 years ago * Smoking history of at least 20 pack-years, or 15 cigarettes/day for 25 years or 10 cigarettes/day for 30 years * Affiliation with a social security scheme * Written informed consent prior to study participation Temporary exclusion Criteria * Chest CT scan performed within the previous 12 months * Signs of respiratory infection (fever, productive cough) Exclusion Criteria: * Severe co-morbidities contraindicating exploration and/or management (including stereotactic surgery or radiotherapy) of lung cancers * Poor general status (PS2 and above) * Rest dyspnea (mMRC4) * Cancer under active surveillance by thoracic computed tomography (CT pr PET-CT) * Personal history of lung cancer * Symptoms raising suspicion of lung cancer (hemoptysis, unexplained weight loss, recent onset or modification of respiratory symptoms,…)
References
Publications (0)
Data not yet available
No reference posted for this study.