Clinical trial · Observational
Simplified Exercise-based Risk Assessment in Lung Cancer
EXercise-based Evaluation of Ventilatory Efficiency for enHanced Risk Assessment in Lungcancer trEatment Using End-tidal CO2: a Multicenter, Prospective Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Physiological evaluation is part of the preoperative risk estimation in patients with lung cancer, and it aids in the choice of treatment. Ventilatory efficiency during exercise has emerged as a strong predictor of major postoperative complications, so far determined during a maximal cardiopulmonary exercise test. However, this test is limited by its availability and high cost, due to the requirement of high-technological equipment and advanced expertise. The current project aims to evaluate a simplified and accessible method for risk evaluation before decision on treatment in lung cancer. It builds on recent advances in technology and knowledge and combines a simple, low-intensity cycling test with measurement of ventilatory efficiency (end-tidal carbon dioxide pressure) with a handheld monitor. In a prospective, multi-center design the investigators will include patients evaluated for suspected lung cancer. The main objective is to establish threshold values for end-tidal carbon dioxide associated with low respectively high risk of major complications in patients undergoing surgery. In addition, the study aims to determine if end-tidal carbon dioxide can predict severe side-effects during neoadjuvant or curatively aiming systemic therapy. The project is closely linked to clinical practice, and the results can be easily implemented due to the simple and cost-efficient methodology. the suggested simplified approach would also allow access to physiological evaluation where more advanced methods are unavailable.
Conditions
Conditions (6)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| End-Tidal Carbon Dioxide | — | UNRESOLVED | — |
| Exercise | — | UNRESOLVED | — |
| Lobectomy | — | UNRESOLVED | — |
| Lung Cancer (Diagnosis) | Malignant Lung Neoplasm | CURATED_EXACT | 0.85 |
| Neoadjuvant Chemoimmunotherapy | — | UNRESOLVED | — |
| Surgery Complications | — | UNRESOLVED | — |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (4)
- label
- Primary objective cohort - Lung cancer lobectomy
- description
- For primary objective, patients undergoing lobectomy for lung cancer will be studied.
- label
- Neoadjuvant treatment cohort
- description
- As one secondary objective, patients with lung cancer undergoing neoadjuvant treatment before surgery or other non-surgical treatment will be studied separately
- label
- Sub-lobular resection cohort
- description
- As one secondary objective, patients undergoing sublobular resection for lung cancer will be studied separately.
- label
- Non-surgical treatment cohort
- description
- As one secondary objective, patients undergoing other treatment than surgery for lung cancer will be studied.
Primary outcomes (1)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Lung Cancer Diagnosis * Age of at least 18 years Exclusion Criteria: * Not able to perform cycle ergometer exercise * Not able to understand spoken or written Swedish
References
Publications (0)
Data not yet available